Loss of TRP53 (p53) accelerates tumorigenesis and changes the tumor spectrum of SJL/J mice
| Autor: | Beth L Dumont, Jane Branca, Rosalinda A Doty, Benjamin E. Low, Michael V Wiles, Muneer G. Hasham, Ruth L Saxl, Jennifer K Sargent |
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| Rok vydání: | 2020 |
| Předmět: |
p53
0301 basic medicine Cancer Research DNA repair SJL/J animal diseases medicine.medical_treatment Biology medicine.disease_cause law.invention 03 medical and health sciences 0302 clinical medicine Immune system law Genetics medicine Gene Chemotherapy Haplotype Immunotherapy tumorigenesis 030104 developmental biology TRP53 030220 oncology & carcinogenesis Cancer research Suppressor Carcinogenesis Research Paper |
| Zdroj: | Genes & Cancer |
| ISSN: | 1947-6027 |
| Popis: | Known as the guardian of the genome, transformation-related protein 53 (TRP53) is a well -known tumor suppressor. Here, we describe a novel TRP53 deficient mouse model on a tumor prone background—SJL/J mice. The absence of TRP53 (TRP53 nullizygosity) leads to a shift in the tumor spectrum from a non-Hodgkin’s-like disease to thymic lymphomas and testicular teratomas at a very rapid tumor onset averaging ~12 weeks of age. In haplotype studies, comparing tumor prone versus tumor resistant Trp53 null mouse strains, we found that other tumor suppressor, DNA repair and/or immune system genes modulate tumor incidence in TRP53 null strains, suggesting that even a strong tumor suppressor such as TRP53 is modulated by genetic background. Due to their rapid development of tumors, the SJL/J TRP53 null mice generated here can be used as an efficient chemotherapy or immunotherapy screening mouse model. |
| Databáze: | OpenAIRE |
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