Serum adiponectin in HIV-1 and hepatitis C virus mono- and co-infected Kenyan injection drug users
| Autor: | Valentine Budambula, Aabid Ahmed, Mark Kilongosi Webale, Eric M. Ndombi, Francis O. Musumba, Erick Mibei, Jesca O Wesongah, Tom Were, Raphael W. Lihana |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
hepatitis C virus
Drug medicine.medical_specialty Waist Endocrinology Diabetes and Metabolism media_common.quotation_subject Hepatitis C virus Human immunodeficiency virus (HIV) anthropometric markers of adiposity medicine.disease_cause Gastroenterology Endocrinology Internal medicine Internal Medicine medicine media_common Hepatitis adiponectin Adiponectin business.industry Surrogate endpoint Research injection drug users HIV virus diseases Anthropometry medicine.disease Immunology anti-retroviral treatment business |
| Zdroj: | Endocrine Connections |
| ISSN: | 2049-3614 |
| DOI: | 10.1530/ec-15-0071 |
| Popis: | Adiponectin is an important marker of anthropometric profiles of adipose tissue. However, association of adiponectin and adiposity in HIV mono- and co-infected and hepatitis (HCV) injection drug users (IDUs) has not been elucidated. Therefore, the relationship of total adiponectin levels with anthropometric indices of adiposity was examined in HIV mono-infected (anti-retroviral treatment, ART-naive, n=16 and -experienced, n=34); HCV mono-infected, n=36; HIV and HCV co-infected (ART-naive, n=5 and -experienced, n=13); uninfected, n=19 IDUs; and healthy controls, n=16 from coastal Kenya. Anthropometric indices of adiposity were recorded and total circulating adiponectin levels were measured in serum samples using enzyme-linked immunosorbent assay. Adiponectin levels differed significantly amongst the study groups (PPost-hoc analyses revealed decreased levels in HIV mono-infected ART-naive IDUs in comparison to uninfected IDUs (PPPPPρ=0.687; P=0.003) and BMI (ρ=0.598; P=0.014) in HIV mono-infected ART-naive IDUs; waist circumference (ρ=−0.626; Pρ=−0.561; P=0.001) circumference, and bust-to-waist ratio (ρ=0.561; P=0.001) in HIV mono-infected ART-experienced IDUs; waist girth (ρ=0.375; P=0.024) in HCV mono-infected IDUs; and waist-to-hip ratio (ρ=−0.872; P=0.048) in HIV and HCV co-infected ART-naive IDUs. Altogether, these results suggest suppression of adiponectin production in treatment-naive HIV mono-infected IDUs and that circulating adiponectin is a useful surrogate marker of altered adiposity in treatment-naive and -experienced HIV and HCV mono- and co-infected IDUs. |
| Databáze: | OpenAIRE |
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