Two cases of multiple spitz nevi: correlating clinical, histologic, and fluorescence in situ hybridization findings
| Autor: | Mary C. Martini, Ashfaq A. Marghoob, Susan L. Boone, Yuqiang Fang, Joan Guitart, Pedram Gerami, Klaus J. Busam |
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| Rok vydání: | 2011 |
| Předmět: |
Pathology
medicine.medical_specialty Skin Neoplasms Adolescent Context (language use) Dermatology Diagnosis Differential Nevus Epithelioid and Spindle Cell Medicine Humans skin and connective tissue diseases Cutaneous metastasis neoplasms In Situ Hybridization Fluorescence Chromosome Aberrations integumentary system medicine.diagnostic_test business.industry Melanoma Diploid cells General Medicine Middle Aged medicine.disease Diploidy Tetraploidy Cutaneous melanoma Fish Female business Fluorescence in situ hybridization |
| Zdroj: | Archives of dermatology. 147(2) |
| ISSN: | 1538-3652 |
| Popis: | Background The occurrence of multiple Spitz nevi is rare, especially the disseminated variant. Multiple Spitz nevi may be confused with, and must be differentiated from, primary spitzoid melanoma and cutaneous melanoma metastases. Over the past decade, fluorescence in situ hybridization (FISH) has emerged as a tool for studying melanocytic neoplasms, helping to differentiate between melanoma and benign melanocytic nevi. We describe 2 cases of patients with multiple Spitz nevi and their FISH results. Observations One case of disseminated Spitz nevi, in a 17-year-old female, showed balanced tetraploidy using FISH, while the other case, in a 51-year-old female with multiple Spitz nevi, showed normal diploid cells without significant gains or losses in chromosomes 6 or 11. Conclusions Patients may present with multiple, even disseminated, Spitz nevi. This phenotype should not be confused with melanoma and/or cutaneous metastasis. The use of FISH studies in context with careful correlation of clinical features and dermoscopic and histologic findings can assist in the diagnostic workup. |
| Databáze: | OpenAIRE |
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