An experimental animal model for percutaneous procedures used in trigeminal neuralgia
| Autor: | Wei-Te Wang, Heber Ferraz-Leite, Helga Bergmeister, Sibylle Kneissl, Romana Höftberger, Johannes Herta, S. Breit |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Percutaneous Balloon Middle cranial fossa 03 medical and health sciences Trigeminal ganglion 0302 clinical medicine Trigeminal neuralgia Electrocoagulation Medicine Animals Humans Animal model Trigeminal Nerve Original Article - Neurosurgical Anatomy Balloon compression Trigeminal nerve business.industry Balloon catheter Percutaneous procedures Balloon Occlusion Trigeminal Neuralgia medicine.disease Cannula Surgery medicine.anatomical_structure Glycerol rhizolysis Trigeminal Ganglion 030220 oncology & carcinogenesis Thermocoagulation Neurology (clinical) Rabbits business Nuclear medicine 030217 neurology & neurosurgery Foramen Ovale |
| Zdroj: | Acta Neurochirurgica |
| ISSN: | 0942-0940 0001-6268 |
| Popis: | Object This study describes an experimental rabbit model that allows the reproduction of percutaneous operations that are used in patients with trigeminal neuralgia (TN). Attention was given to an exact anatomical description of the rabbit’s middle cranial fossa as well as the establishment of conditions for a successful procedure. Methods Morphometric measurements were taken from 20 rabbit skulls and CT scans. The anatomy of the trigeminal nerve, as well as its surrounding structures, was assessed by bilateral dissection of 13 New Zealand white rabbits (NWR). An ideal approach of placing a needle through the foramen ovale to reach the TG was sought. Validation of correct placement was realized by fluoroscopy and confirmed by dissection. Results Precise instructions for successful reproduction of percutaneous procedures in NWR were described. According to morphological measurements, for balloon compression of the trigeminal ganglion (TG) the maximal diameter of an introducing cannula is 1.85 mm. The diameter of an empty balloon catheter should not exceed 1.19 mm, and the length of the inflatable part of the balloon can range up to 4 mm. For thermocoagulation the needle electrodes must not exceed an external diameter of 1.39, mm and the length of the non-insolated tip can range up to 4 mm. Glycerol rhizolysis can be achieved because the trigeminal cistern in the NWR is a closed space that allows a long dwelling time (>10 min) of the contrast agent. Conclusions An experimental NWR model intended for the reproduction of percutaneous procedures on the TG has been meticulously described. This provides a tool that enables further standardized animal research in the field of surgical treatment of TN. Electronic supplementary material The online version of this article (doi:10.1007/s00701-017-3162-8) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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