Problems of biopsy and diagnosis in a cooperative study of osteosarcoma

Autor: W. Ramach, Günter Delling, W. Becker
Rok vydání: 1983
Předmět:
Zdroj: Journal of Cancer Research and Clinical Oncology. 106:11-13
ISSN: 1432-1335
0171-5216
DOI: 10.1007/bf00625044
Popis: Biopsy is a highly responsible procedure which can determine the patient's fate. First we ask for the necessity of biopsy. Whereas formerly the diagnosis of a malignant bone tumor was almost always followed by amputation and X-ray therapy was restricted to more or less palliative measures, nowadays we have highly sophisticated therapeutic regimens for the different histologic tumor types and locations. Not only are there tumor-specific therapeutic procedures but, to a certain degree, even individual variations may be considered. Recently Marcove (1980) pointed to this individual planning of the treatment. Responsible and specifically designed therapy calls for a diagnosis that is not only highly accurate but also takes into account fine distinctions within the tumor itself. This is summarized in the term "histologic grading". Only this exact analysis of the individual situation together with the knowledge of localization and extent of the tumor allows individual programs. Biopsy of the tumor before the commencement of treatment is essential to judge the success of any form of presurgical therapy, be it chemotherapy, X-ray therapy or combinations of both. The question therefore arises what dangers, if any, are connected with biopsy. Generally, there is the danger of systemic and local spread of the tumor. We will deal with local spread later in connection with the discussion about the performance of biopsy. The danger of systemic spread has been recognized ever since. Jaffe (1958) pointed out the danger ofunneccessary trauma to the tumor and in 1977 Dominok and Knoch still discussed the problem of how to avoid enhancing metastases by the pro
Databáze: OpenAIRE
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