Disruption of the Oral Microbiota Is Associated With a Higher Risk of Relapse After Allogeneic Hematopoietic Stem Cell Transplantation
| Autor: | Wanessa Miranda-Silva, Anamaria A. Camargo, Eduardo Rodrigues Fregnani, Franciele Hinterholz Knebel, Paula Fontes Asprino, Vanderson Rocha, Celso Arrais-Rodrigues, Luciana Tucunduva, Vitor Heidrich, Julia Stephanie Bruno, Vinicius Campos de Molla, Yana Novis |
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| Rok vydání: | 2021 |
| Předmět: |
Adult
Male medicine.medical_specialty Transplantation Conditioning medicine.medical_treatment Science Hematopoietic stem cell transplantation Gastroenterology Article Young Adult Risk Factors Internal medicine Medicine Humans Transplantation Homologous Relapse risk Oral mucosa Dominance (genetics) Aged Multidisciplinary Leukemia business.industry Haematopoietic stem cells Microbiota Hematopoietic Stem Cell Transplantation Mouth Mucosa Aplasia Translational research Middle Aged medicine.disease Transplantation Survival Rate medicine.anatomical_structure Treatment Outcome Female Stem cell Neoplasm Recurrence Local business Dysbiosis Brazil |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021) Scientific Reports |
| DOI: | 10.21203/rs.3.rs-512884/v1 |
| Popis: | Background: Intestinal microbiota (IM) diversity and composition regulates host immunity and affects outcomes after allogeneic stem cell transplantation (allo-HSCT). Methods: We evaluated how the oral mucosa microbiota (OM) impacts the outcomes in patients who underwent allo-HSCT. Samples from the oral mucosa of 30 patients were collected at three time points: before the conditioning, at aplasia, and at engraftment. We analyzed the associations of OM diversity and composition with allo-HSCT outcomes. Results: Higher OM diversity at preconditioning was associated with a lower risk of relapse in 3 years (33% versus 68%, respectively; P = 0.04). Dominance (relative abundance ≥30%) by a single genus at preconditioning was associated with a higher risk of relapse (63% versus 36%, respectively; P = 0.04), worse progression-free survival (PFS; 19% versus 55%, respectively; P = 0.01), and poorer overall survival (OS) at 3 years (38% versus 81%, respectively; P= 0.02). Conclusion: The presence of Solobacterium at preconditioning was associated with a lower risk of relapse (9% versus 56%, respectively; P = 0.04). This is the first study to address the relationship between OM and clinical outcomes after allo-HSCT. |
| Databáze: | OpenAIRE |
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