Local Anaesthetic Activity in Diethylaminoacetyl Derivatives of Substituted Benzylamines

Autor:	R. F. Collins, B. J. Large
Rok vydání:	1962
Předmět:	Pharmacology Benzylamines Necrosis Local anaesthetic integumentary system Erythema Chemistry Pharmaceutical Science Anesthesia Tissue damage medicine Intradermal injection Amines Anesthetics Local medicine.symptom All cause mortality Anesthesia Local
Zdroj:	Journal of Pharmacy and Pharmacology. 14:48T-58T
ISSN:	2042-7158 0022-3573
DOI:	10.1111/j.2042-7158.1962.tb10529.x
Popis:	Six diethylaminoacetyl derivatives of general formula (III) are more potent than lignocaine as local anaesthetics. All cause erythema or necrosis of guinea-pig skin on intradermal injection except III, R = NH2, R' = H, and R = O(CH2)2Ph. This compound is several times more potent than lignocaine and in equipotent concentrations did not cause any tissue damage to skin on intradermal injection.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95241bd8f2af38cc22e853faf3445057 https://doi.org/10.1111/j.2042-7158.1962.tb10529.x Zobrazit plný text záznamu Plný text