Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer

Autor: Louis Vermeulen, Antonia K. Roseweir, Ian Tomlinson, Paul G. Horgan, Janet Graham, Donald C. McMillan, Sanne ten Hoorn, Elizabeth Ryan, David N. Church, Arfon Powell, Susan Aherne, Joanne Edwards, Owen J. Sansom, James Paul, Timothy Iveson, Campbell S.D. Roxburgh, Mark N. K. Saunders, Kieran Sheahan, James H. Park, Andrea Harkin
Přispěvatelé: Center of Experimental and Molecular Medicine, AGEM - Re-generation and cancer of the digestive system, CCA - Cancer biology and immunology
Rok vydání: 2020
Předmět:
Male
Oncology
medicine.medical_specialty
Time Factors
recurrence
Organoplatinum Compounds
subtyping
Colorectal cancer
precision medicine
medicine.medical_treatment
Leucovorin
adjuvant treatment
colorectal cancer
Risk Assessment
Disease-Free Survival
Pathology and Forensic Medicine
FOLFOX
Predictive Value of Tests
Risk Factors
Internal medicine
Antineoplastic Combined Chemotherapy Protocols
lcsh:Pathology
medicine
Clinical endpoint
Humans
Prospective Studies
Stage (cooking)
Aged
Neoplasm Staging
Chemotherapy
business.industry
Reproducibility of Results
Original Articles
Middle Aged
medicine.disease
Subtyping
Phenotype
Chemotherapy
Adjuvant
Cohort
histopathology
Original Article
Female
Histopathology
Fluorouracil
Neoplasm Recurrence
Local
Colorectal Neoplasms
business
lcsh:RB1-214
medicine.drug
Zdroj: journal of pathology. Clinical research, 6(4), 283-296. Wiley-Blackwell Publishing Ltd
The Journal of Pathology: Clinical Research, Vol 6, Iss 4, Pp 283-296 (2020)
Roseweir, A K, Park, J H, Hoorn, S T, Powell, A G, Aherne, S, Roxburgh, C S, Mcmillan, D C, Horgan, P G, Ryan, E, Sheahan, K, Vermeulen, L, Paul, J, Harkin, A, Graham, J, Sansom, O, Church, D N, Tomlinson, I, Saunders, M, Iveson, T J & Edwards, J 2020, ' Histological phenotypic subtypes predict recurrence risk and response to adjuvant chemotherapy in patients with stage III colorectal cancer ', Journal of Pathology: Clinical Research . https://doi.org/10.1002/cjp2.171, https://doi.org/10.1002/cjp2.171
The Journal of Pathology: Clinical Research
ISSN: 2056-4538
Popis: Histological ‘phenotypic subtypes’ that classify patients into four groups (immune, canonical, latent and stromal) have previously been demonstrated to stratify survival in a stage I–III colorectal cancer (CRC) pilot cohort. However, clinical utility has not yet been validated. Therefore, this study assessed prognostic value of these subtypes in additional patient cohorts along with associations with risk of recurrence and response to chemotherapy. Two independent stage I–III CRC patient cohorts (internal and external cohort) were utilised to investigate phenotypic subtypes. The primary endpoint was disease‐free survival (DFS) and the secondary endpoint was recurrence risk (RR). Stage II–III patients, from the SCOT adjuvant chemotherapy trial, were utilised to further validate prognostic value and for exploratory analysis assessing associations with adjuvant chemotherapy. In an 893‐patient internal cohort, phenotypic subtype independently associated with DFS (p = 0.025) and this was attenuated in stage III patients (p = 0.020). Phenotypic subtype also independently associated with RR (p
Databáze: OpenAIRE
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