Novel Biomarkers of Acute Kidney Toxicity
| Autor: | Aliza Thompson, P. Harlow, Federico Goodsaid, Melanie Blank, Frank D. Sistare, Frank Dieterle, Elizabeth A. Hausner, Jacky Vonderscher |
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| Rok vydání: | 2009 |
| Předmět: |
Proteomics
Pharmacology Risk Management Drug-Related Side Effects and Adverse Reactions Kidney Toxicity business.industry Drug Evaluation Preclinical Acute kidney injury Genomics Computational biology Acute Kidney Injury medicine.disease Drug development Drug Design Models Animal Animals Humans Medicine Pharmacology (medical) Biomarker discovery business Biomarkers |
| Zdroj: | Clinical Pharmacology & Therapeutics. 86:490-496 |
| ISSN: | 1532-6535 0009-9236 |
| Popis: | Novel biomarkers of kidney toxicity are powerful tools not only with respect to their clinical applications but also because of their impact on drug development. These biomarkers can influence the assessment of efficacy of new drugs for kidney diseases as well as the risk management for new drugs. The science behind these novel biomarkers reflects the evolution over the past decade of genomic and proteomic platforms that have transformed the discovery and development of new biomarkers for preclinical and clinical applications in drug development. Several of these biomarkers are in use as transcriptomic biomarkers in animal models as well as translational proteomic biomarkers in animal models and in humans. Their ability to detect kidney damage earlier than is possible with currently accessible biomarkers is being given qualification through regulatory biomarker-qualification programs, which will help establish consensus for their widespread use. |
| Databáze: | OpenAIRE |
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