Proposed refined diagnostic criteria and classification of eosinophil disorders and related syndromes
Autor: | Peter Valent, Amy D. Klion, Florence Roufosse, Dagmar Simon, Georgia Metzgeroth, Kristin M. Leiferman, Juliana Schwaab, Joseph H. Butterfield, Wolfgang R. Sperr, Karl Sotlar, Peter Vandenberghe, Gregor Hoermann, Torsten Haferlach, Richard Moriggl, Tracy I. George, Cem Akin, Bruce S. Bochner, Jason Gotlib, Andreas Reiter, Hans‐Peter Horny, Michel Arock, Hans‐Uwe Simon, Gerald J. Gleich |
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Rok vydání: | 2022 |
Předmět: |
Allergy
FEATURES VARIANT Immunology IMATINIB MESYLATE eosinophilic leukemia Eosinophilia Hypereosinophilic Syndrome Hypersensitivity Humans Immunology and Allergy INTERLEUKIN-5 610 Medicine & health HYPEREOSINOPHILIC SYNDROME Science & Technology RECEPTOR CYTOKINES personalized medicine Syndrome Eosinophils classification DISEASES diagnostic criteria HEALTH Life Sciences & Biomedicine RESPONSES |
Zdroj: | Allergy. 78:47-59 |
ISSN: | 1398-9995 0105-4538 |
Popis: | Eosinophilia and eosinophil activation are recurrent features in various reactive states and certain hematologic malignancies. In patients with hypereosinophilia (HE), HE-induced organ damage is often encountered and may lead to the diagnosis of a hypereosinophilic syndrome (HES). A number of known mechanisms and etiologies contribute to the development of HE and HES. Based on these etiologies and the origin of eosinophils, HE and HES are divided into primary forms where eosinophils are clonal cells, reactive forms where an underlying reactive or neoplastic condition is detected and eosinophils are considered to be "non-clonal" cells, and idiopathic HE and HES in which neither a clonal nor a reactive underlying pathology is detected. Since 2012, this classification and the related criteria have been widely accepted and regarded as standard. However, during the past few years, new developments in the field and an increasing number of markers and targets have created a need to update these criteria and the classification of HE and HES. To address this challenge, a Working Conference on eosinophil disorders was organized in 2021. In this conference, a panel of experts representing the relevant fields, including allergy, dermatology, hematology, immunology, laboratory medicine, and pathology, met and discussed new markers and concepts as well as refinements in definitions, criteria and classifications of HE and HES. The outcomes of this conference are presented in this article and should assist in the diagnosis and management of patients with HE and HES in daily practice and in the preparation and conduct of clinical trials. ispartof: ALLERGY vol:78 issue:1 pages:47-59 ispartof: location:Denmark status: published |
Databáze: | OpenAIRE |
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