Effects of parental and household smoking on the risk of respiratory syncytial virus (RSV) hospitalisation in late-preterm infants and the potential impact of RSV prophylaxis
| Autor: | Katherine L. Gooch, Johannes G. Liese, Pamela G. Vo, John R. Fullarton, Marcello Lanari, Jean-Bernard Gouyon, Xavier Carbonell-Estrany, José Figueras-Aloy |
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| Přispěvatelé: | Neonatology, Hospital Clinic, Centre d'Études Périnatales de l'Océan Indien (CEPOI), Université de La Réunion (UR)-Centre Hospitalier Universitaire de La Réunion (CHU La Réunion), CHU Saint-Pierre, Carbonell-Estrany, Xavier, Fullarton, John R, Gooch, Katherine L, Vo, Pamela G, Figueras-Aloy, Jose, Lanari, Marcello, Gouyon, Jean-Bernard, Liese, Johannes G |
| Rok vydání: | 2013 |
| Předmět: |
Parents
Pediatrics Diseases Infant Premature Diseases medicine.disease_cause Cohort Studies 0302 clinical medicine Risk Factors Monoclonal 030212 general & internal medicine Antibiotic prophylaxis Humanized Family Characteristics Obstetrics and Gynecology Gestational age 3. Good health Hospitalization Respiratory syncytial virus (RSV) Infant Premature Family Characteristic Human Cohort study medicine.drug Palivizumab medicine.medical_specialty Gestational Age Respiratory Syncytial Virus Infections Antibodies Monoclonal Humanized Antibodies 03 medical and health sciences 030225 pediatrics antiviral agents medicine Antibiotic Prophylaxi Humans Risk factor Premature Antiviral Agent Respiratory Syncytial Virus Infection [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics business.industry Risk Factor Infant Newborn Infant Infant Premature Disease Antibiotic Prophylaxis Newborn medicine.disease Confidence interval Parent Bronchiolitis Pediatrics Perinatology and Child Health Tobacco Smoke Pollution Cohort Studie business |
| Zdroj: | Journal of Maternal-Fetal and Neonatal Medicine Journal of Maternal-Fetal and Neonatal Medicine, Taylor & Francis, 2013, 26 (9), pp.926--931. ⟨10.3109/14767058.2013.765850⟩ |
| ISSN: | 1476-4954 1476-7058 |
| Popis: | International audience; OBJECTIVE: To assess the impact of household smoking and palivizumab prophylaxis on the risk of respiratory syncytial virus (RSV) hospitalisation in late-preterm (32-35 weeks' gestational age) infants. METHODS: Familial smoking and other RSV risk factor data from the FLIP, FLIP-2 and IMpact studies and datasets from France, Germany and Italy, together with palivizumab prophylaxis data from the FLIP-2 and IMpact studies, were analysed using cross-correlation and Bayesian meta-analytical modelling employing Markov Chain Monte Carlo sampling. RESULTS: There were 2.35 times (95% confidence interval [CI] 1.37-4.02) as many hospitalisations amongst infants from smoking compared with those from non-smoking families. Among non-prophylaxed infants, there were 2.53 times (95% CI 1.27-4.94) as many RSV hospitalisations from smoking than from non-smoking families and that excess hospitalisation was reduced to 1.03 times (95% CI 0.38-2.99) amongst prophylaxed infants. Familial smoking correlates significantly (p \textless 0.01) with other RSV risk factors: positive correlation with number of school-age siblings, history of family atopy, family wheeze and gestational age; negative correlation with birth weight and breast feeding. CONCLUSIONS: Late-preterm infants from smoking families appear to be at heightened risk for severe RSV infection requiring hospitalisation of which the risk may be reduced with RSV prophylaxis. |
| Databáze: | OpenAIRE |
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