The association between ST18 gene polymorphism and severe pemphigus disease among Iranian population
| Autor: | Ifa Etesami, Hamzeh Salmani, Maryam Daneshpazhooh, Amir Teimourpour, Hassan Seirafi, Maedeh Arabpour, Ali Nasrollahzadeh, Narges Ghandi, Mohammad Keramatipour |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Adult Keratinocytes Male Genotype Single-nucleotide polymorphism Dermatology Disease Iran Biochemistry Polymorphism Single Nucleotide 03 medical and health sciences Gene Frequency Risk Factors medicine SNP Humans Genetic Predisposition to Disease Allele Family history Promoter Regions Genetic Molecular Biology Alleles integumentary system business.industry Middle Aged medicine.disease Repressor Proteins Pemphigus 030104 developmental biology Case-Control Studies Immunology Cytokine secretion Female Gene polymorphism business |
| Zdroj: | Experimental dermatology. 27(12) |
| ISSN: | 1600-0625 |
| Popis: | Recently, ST18 polymorphism has played a role in increasing the risk of pemphigus among some populations such as Egyptian and Jewish. In addition, a variant within the ST18 promoter gene was shown to induce ST18 upregulation and cytokine secretion leading to keratinocyte susceptibility to anti-desmoglein antibodies. Thus, the present study aimed to assess the ST18 single nucleotide polymorphisms (SNP) relationship with pemphigus, disease severity and family history among Iranian population. A total of 111 pemphigus patients and 201 healthy controls were genotyped for three ST18 SNPs rs2304365, rs10504140 and rs4074067 by using TETRA-ARMS PCR method. The results indicated that risk allele A in rs2304365 was significantly higher in pemphigus patients, compared with the amount in the control group (OR = 2.43 CI = 1.49-3.975, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |