| Autor: |
Bruno, A, Dolcetti, E, Azzolini, F, Buttari, F, Gilio, L, Iezzi, E, Galifi, G, Borrelli, A, Furlan, R, Finardi, A, Carbone, F, De Vito, F, Musella, A, Guadalupi, L, Mandolesi, G, Matarese, G, Centonze, D, Stampanoni Bassi, M |
| Přispěvatelé: |
Bruno, Antonio, Dolcetti, Ettore, Azzolini, Federica, Buttari, Fabio, Gilio, Luana, Iezzi, Ennio, Galifi, Giovanni, Borrelli, Angela, Furlan, Roberto, Finardi, Annamaria, Carbone, Fortunata, De Vito, Francesca, Musella, Alessandra, Guadalupi, Livia, Mandolesi, Georgia, Matarese, Giuseppe, Centonze, Diego, Stampanoni Bassi, Mario |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
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| Popis: |
Neurodegenerative and inflammatory processes influence the clinical course of multiple sclerosis (MS). The β-site amyloid precursor protein cleaving enzyme 1 (BACE1) has been associated with cognitive dysfunction, amyloid deposition and neuroinflammation in Alzheimer's disease. We explored in a group of 50 patients with relapsing-remitting MS the association between the cerebrospinal fluid (CSF) levels of BACE1, clinical characteristics at the time of diagnosis and prospective disability after three-years follow-up. In addition, we assessed the correlations between the CSF levels of BACE 1, amyloid β (Aβ) 1-40 and 1-42, phosphorylated tau (pTau), lactate, and a set of inflammatory and anti-inflammatory molecules. BACE1 CSF levels were correlated positively with depression as measured with Beck Depression Inventory-Second Edition scale, and negatively with visuospatial memory performance evaluated by the Brief Visuospatial Memory Test-Revised. In addition, BACE CSF levels were positively correlated with Bayesian Risk Estimate for MS at onset, and with Expanded Disability Status Scale score assessed three years after diagnosis. Furthermore, a positive correlation was found between BACE1, amyloid β 42/40 ratio (Spearman's r = 0.334, p = 0.018, n = 50), pTau (Spearman's r = 0.304, p = 0.032, n = 50) and lactate concentrations (Spearman's r = 0.361, p = 0.01, n = 50). Finally, an association emerged between BACE1 CSF levels and a group of pro and anti-inflammatory molecules, including interleukin (IL)-4, IL-17, IL-13, IL-9 and interferon-γ. BACE1 may have a role in different key mechanisms such as neurodegeneration, oxidative stress and inflammation, influencing mood, cognitive disorders and disability progression in MS. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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