Different mechanical loading protocols influence serum cartilage oligomeric matrix protein levels in young healthy humans
| Autor: | S. Helling, Joachim Maurer, Gert-Peter Brüggemann, Jens Dargel, Anja Niehoff, Uwe G. Kersting, Mario Thevis |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
musculoskeletal diseases
Adult Male medicine.medical_specialty animal structures Physiology Movement Physical activity Articular cartilage Physical exercise Cartilage Oligomeric Matrix Protein Running Lymphatic System Weight-Bearing Young Adult fluids and secretions Physiology (medical) Internal medicine medicine Synovial fluid Humans Matrilin Proteins Orthopedics and Sports Medicine Knee Exercise Glycoproteins Cartilage oligomeric matrix protein Extracellular Matrix Proteins biology Chemistry Cartilage Public Health Environmental and Occupational Health General Medicine Serum concentration musculoskeletal system carbohydrates (lipids) Endocrinology Lymphatic system medicine.anatomical_structure Immunology biology.protein Exercise Test Drainage Stress Mechanical |
| Zdroj: | Niehoff, A, Kersting, U G, Helling, S, Dargel, J, Maurer, J, Thevis, M & Brüggemann, G-P 2010, ' Different mechanical loading protocols influence serum cartilage oligomeric matrix protein levels in young healthy humans ', European Journal of Applied Physiology, vol. 110, no. 3, pp. 651-657 . https://doi.org/10.1007/s00421-010-1529-0 |
| Popis: | The purpose of the study was to investigate whether a relationship between the loading mode of physical activity and serum cartilage oligomeric matrix protein (COMP) concentration exists and whether the lymphatic system contributes to COMP release into the serum. Serum COMP levels were determined in healthy male subjects before, after and at 18 further time points within 7 h at four separate experimental days with four different loading interventions. The loading intervention included high impact running exercise, slow but deep knee bends, and lymphatic drainage of 30 min duration, respectively, and a resting protocol. The serum COMP levels were measured using a commercially available quantitative enzyme-linked immunosorbent assay. An increase (p < 0.001) in serum COMP concentration was detected immediately after 30 min running exercise. Slow but deep knee bends did not cause any significant changes in serum COMP levels. Lymphatic drainage also had no effect on the serum COMP concentration. After 30 min of complete rest the serum COMP level was significantly (p = 0.008) reduced. The elevation of COMP serum concentration seems to depend on the loading mode of the physical activity and to reflect the extrusion of COMP fragments from the impact loaded articular cartilage or synovial fluid. |
| Databáze: | OpenAIRE |
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