Retraction Note: Transplantation of Mouse Induced Pluripotent Stem Cell-Derived Podocytes in a Mouse Model of Membranous Nephropathy Attenuates Proteinuria
| Autor: | Mehdi Alikhani, Vahid Ezzatizadeh, Mohammad Hassan Asghari-Vostikolaee, Seyed Mahdi Nassiri, Reza Salman Yazdi, Zeinab Taghizadeh, Reza Moghadasali, Hossein Baharvand, Nasser Aghdami, Reza Rahbarghazi, Amin Ahmadi, Fatemeh Hadi |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Kidney
Pathology medicine.medical_specialty Multidisciplinary Proteinuria business.industry Science Glomerulonephritis Glomerulus (kidney) medicine.disease Transplantation medicine.anatomical_structure Membranous nephropathy Heavy proteinuria medicine Medicine medicine.symptom Induced pluripotent stem cell business |
| Zdroj: | Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021) |
| ISSN: | 2045-2322 |
| Popis: | Injury to podocytes is a principle cause of initiation and progression of both immune and non-immune mediated glomerular diseases that result in proteinuria and decreased function of the kidney. Current advances in regenerative medicine shed light on the therapeutic potential of cell-based strategies for treatment of such disorders. Thus, there is hope that generation and transplantation of podocytes from induced pluripotent stem cells (iPSCs), could potentially be used as a curative treatment for glomerulonephritis caused by podocytes injury and loss. Despite several reports on the generation of iPSC-derived podocytes, there are rare reports about successful use of these cells in animal models. In this study, we first generated a model of anti-podocyte antibody-induced heavy proteinuria that resembled human membranous nephropathy and was characterized by the presence of sub-epithelial immune deposits and podocytes loss. Thereafter, we showed that transplantation of functional iPSC-derived podocytes following podocytes depletion results in recruitment of iPSC-derived podocytes within the damaged glomerulus, and leads to attenuation of proteinuria and histological alterations. These results provided evidence that application of iPSCs-derived renal cells could be a possible therapeutic strategy to favorably influence glomerular diseases outcomes. |
| Databáze: | OpenAIRE |
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