Exposure to DDT and diabetic nephropathy among Mexican Americans in the 1999–2004 National Health and Nutrition Examination Survey

Autor: Olivia M. Thompson, Clara E. Dismuke, Charles J. Everett
Rok vydání: 2017
Předmět:
Adult
Male
medicine.medical_specialty
Adolescent
National Health and Nutrition Examination Survey
Health
Toxicology and Mutagenesis
Population
010501 environmental sciences
Toxicology
01 natural sciences
DDT
Nephropathy
Diabetic nephropathy
Young Adult
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Diabetes mellitus
Mexican Americans
Odds Ratio
medicine
Humans
Diabetic Nephropathies
030212 general & internal medicine
Pesticides
Child
education
Aged
0105 earth and related environmental sciences
education.field_of_study
business.industry
General Medicine
Odds ratio
Middle Aged
Nutrition Surveys
medicine.disease
Pollution
United States
Endocrinology
Diabetes Mellitus
Type 2
Dichlorodiphenyldichloroethylene
chemistry
Female
Microalbuminuria
business
Demography
Zdroj: Environmental Pollution. 222:132-137
ISSN: 0269-7491
Popis: Concentrations of the pesticide DDT (dichlorodiphenyltrichloroethane) and its metabolite DDE (dichlorodiphenyldichloroethylene), in the blood of Mexican Americans, were evaluated to determine their relationships with diabetes and diabetic nephropathy. The data were derived from the National Health and Nutrition Examination Survey (NHANES) 1999–2004 (unweighted N = 1,411, population estimate = 13,760,609). The sample included teens, 12–19 years old, which accounted for 19.8% of the data. The time of the study overlapped the banning of DDT in Mexico in the year 2000, and those participants born in Mexico were exposed to DDT before they immigrated to the US. We sought to better understand the relationship of DDT with diabetes in a race/ethnicity group prone to develop diabetes and exposed to DDT. In this study, nephropathy was defined as urinary albumin to creatinine ratio >30 mg/g, representing microalbuminuria and macroalbuminuria, and total diabetes was defined as diagnosed and undiagnosed diabetes (glycohemoglobin, A1c ≥ 6.5%). The proportion with the isomer p,p′- DDT >0.086 ng/g (above the maximum limit of detection) was 13.3% for Mexican Americans born in the US, and 36.9% for those born in Mexico. Levels of p,p′- DDT >0.086 ng/g were associated with total diabetes with nephropathy (odds ratio = 4.42, 95% CI 2.23–8.76), and with total diabetes without nephropathy (odds ratio = 2.02, 95% CI 1.19–3.44). The third quartile of p,p′- DDE (2.99–7.67 ng/g) and the fourth quartile of p,p′- DDE (≥7.68 ng/g) were associated with diabetic nephropathy and had odds ratios of 5.32 (95% CI 1.05–26.87) and 14.95 (95% CI 2.96–75.48) compared to less than the median, respectively, whereas p,p′- DDE was not associated with total diabetes without nephropathy. The findings of this study differ from those of a prior investigation of the general adult US population in that there were more associations found with the Mexican Americans sample.
Databáze: OpenAIRE
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