Enhanced complement activation is part of the unfavourable cardiovascular risk profile in South Asians
| Autor: | Mohamed R. Daha, P.K. Chandie Shaw, Ton J. Rabelink, R. N. Van Der Geest, Stefan P Berger, Tom Eirik Mollnes, Machiel A. Siezenga |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Risk medicine.medical_specialty Translational Studies Immunology Inflammation Complement Membrane Attack Complex Statistics Nonparametric Asian People Internal medicine Diabetes mellitus medicine Albuminuria Humans Immunology and Allergy Risk factor Complement Activation Asia Southeastern Aged Netherlands Traditional medicine business.industry Case-control study Complement C3 Odds ratio Middle Aged medicine.disease Complement system Diabetes Mellitus Type 2 Cardiovascular Diseases Case-Control Studies Female medicine.symptom Complement membrane attack complex business Biomarkers |
| Zdroj: | Clinical and Experimental Immunology. 157:98-103 |
| ISSN: | 1365-2249 0009-9104 |
| DOI: | 10.1111/j.1365-2249.2009.03959.x |
| Popis: | SummarySouth Asian immigrants in western societies exhibit a high burden of diabetes and subsequent vascular complications. Diabetic vascular complications are associated with vascular inflammation. We hypothesize that enhanced complement activation is involved. Therefore, levels of complement C3 and SC5b-9 – the soluble end product of complement activation – in a group of 200 South Asians were compared with an age- and sex-matched control group of native Caucasians. In addition, the association between complement levels and albuminuria, an indicator of renal damage and a cardiovascular risk marker, was assessed in the diabetic South Asian group. Compared with native Caucasians, South Asians had significantly higher levels of both serum C3 and plasma SC5b-9, even when only non-diabetic South Asians were considered. Diabetic South Asians had significantly higher C3 levels compared with non-diabetic South Asians. In diabetic South Asians, higher levels of SC5b-9 were associated with an increased prevalence of albuminuria (odds ratio 5·4, 95% confidence interval 1·8–15·8). These results suggest that enhanced complement activation is part of the unfavourable cardiovascular risk profile in South Asians. |
| Databáze: | OpenAIRE |
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