Towards the impedimetric tracking of single magnetically trailed microparticles
| Autor: | Riccardo Bertacco, Matteo Cantoni, Marco Sampietro, Marco Carminati, Marco Monticelli, Edoardo Albisetti, Daniela Petti, Giorgio Ferrari, Andrea Mario Torti, S. U. Kwon |
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| Rok vydání: | 2014 |
| Předmět: |
Magnetic beads
Materials science business.industry drug delivery impedance detection microelectrodes Signal Processing Control and Systems Engineering Lab-on-a-chip Noise (electronics) law.invention Microelectrode law Phase noise Electronic engineering Magnetic nanoparticles Optoelectronics business Phase shift module Electrical impedance Active noise control |
| Zdroj: | SSD |
| DOI: | 10.1109/ssd.2014.6808828 |
| Popis: | We present the design and the preliminary experimental characterization of a novel lab-on-a-chip platform for high-sensitivity impedimetric detection of single magnetic beads employed as magnetic cargos with molecular payload for accurate drug delivery. The real-time impedimetric detection of these superparamagnetic microbeads in saline solution is here experimentally demonstrated (20 nS conductance variation for a single 1μm bead), validating the insulating-sphere model and the finite-element simulations employed for optimal electrode design. A custom electronic front-end for impedance tracking in the 1-10 MHz range, required to compensate the impact of the large parasitic impedance due to the silicon substrate, is also presented. Thanks to introduction of an ad-hoc noise cancelling network based on a dummy circuit and a phase shifter for low-frequency phase noise counteraction by active subtraction, slow fluctuations are significantly reduced (by a factor 10), allowing a SNR > 10. |
| Databáze: | OpenAIRE |
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