Identification of the major urinary and fecal metabolites of 3,5-dinitrobenzamide in chickens and rats
| Autor: | Jerome E. Bakke, N.W. Shappell, Gerald L. Larsen |
|---|---|
| Rok vydání: | 1999 |
| Předmět: |
Male
medicine.medical_specialty Coccidiostat Environmental Engineering Health Toxicology and Mutagenesis Metabolite Urinary system Antiprotozoal Agents Administration Oral Urine Biology Excretion Rats Sprague-Dawley chemistry.chemical_compound Feces Oral administration Internal medicine Colostomy medicine Environmental Chemistry Animals Public Health Environmental and Occupational Health General Medicine General Chemistry Metabolism Pollution Animal Feed Rats carbohydrates (lipids) Endocrinology chemistry Benzamides Food Additives Chickens |
| Zdroj: | Chemosphere. 38(8) |
| ISSN: | 0045-6535 |
| Popis: | Colostomized chickens given oral doses of 3,5-dinitrobenzamide (nitromide) cleared nitromide predominantly through the urine (58% of dose) and feces (21% of dose). Rats cleared 52% of nitromide via urinary excretion and 44% via feces. Major urinary metabolites for both chickens and rats include: 3-amino-5-nitrobenzamide, 3-acetamido-5-nitrobenzamide, 3-acetamide-5-aminobenzamide, and 3,5-diacetamidobenzamide. The major fecal metabolite in chickens was 3-acetamido-5-nitrobenzamide (67% of fecal 14C) and 3-acetamido-5-aminobenzamide in rats (approximately 50%). |
| Databáze: | OpenAIRE |
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