HPV-associated anal lesions in HIV+ patients: long-term results regarding quality of life
| Autor: | Christoph Boesecke, Carolynne Schwarze-Zander, Martin W. von Websky, Paul C. Wesselmann, Tim O. Vilz, Tim R. Glowka, Jörg C. Kalff, B Stoffels, Jürgen K. Rockstroh |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
Quality of life
Adult Male medicine.medical_specialty HPV Time Factors SF-36 Adolescent Sexual Behavior Human immunodeficiency virus (HIV) Condyloma medicine.disease_cause Anal intraepithelial neoplasia Anal lesions 03 medical and health sciences Young Adult 0302 clinical medicine Recurrence Internal medicine Surveys and Questionnaires HIV Seropositivity medicine Humans 030212 general & internal medicine business.industry Gastroenterology HIV Anal dysplasia Hepatology Middle Aged medicine.disease Anus Neoplasms Condylomata Acuminata Concomitant Hiv patients 030211 gastroenterology & hepatology Original Article Neoplasm Recurrence Local business Carcinoma in Situ Stress Psychological Follow-Up Studies |
| Zdroj: | International Journal of Colorectal Disease |
| ISSN: | 1432-1262 0179-1958 |
| Popis: | Purpose HIV infection and concomitant HPV-associated anal lesions may significantly impact on patients’ quality of life (QoL), as they are predicted to have negative effects on health, psyche, and sexuality. Material and methods Fifty-two HIV+ patients with HPV-associated anal lesions were enrolled in a survey approach after undergoing routine proctologic assessment and therapy for HPV-associated anal lesions if indicated over a time span of 11 years (11/2004–11/2015). Therapy consisted of surgical ablation and topic treatment. QoL was analyzed using the SF-36 and the CECA questionnaires. Results Fifty-two of 67 patients (77.6%) were successfully contacted and 29/52 provided full information. The mean age was 43.8 ± 12.8 years. The median follow-up from treatment to answering of the questionnaire was 34 months. Twenty-one percent (6/29) of the patients reported suffering from recurrence of condyloma acuminata, three patients from anal dysplasia (10.3%). In the SF-36, HIV+ patients did not rate their QoL as significantly different over all items after successful treatment of HPV-associated anal lesions. In the CECA questionnaire, patients with persisting HPV-associated anal lesions reported significantly higher emotional stress levels and disturbance of everyday life compared to patients who had successful treatment (71.9/100 ± 18.7 vs. 40.00/100 ± 27.4, p = 0.004). Importantly, the sexuality of patients with anal lesions was significantly impaired (59.8/100 ± 30.8 vs. 27.5/100 ± 12.2, p = 0.032). Conclusion HPV-associated anal lesions impact significantly negative on QoL in HIV+ patients. Successful treatment of HPV-associated anal lesions in HIV+ patients improved QoL. Specific questionnaires, such as CECA, seem to be more adequate than the SF-36 in this setting. |
| Databáze: | OpenAIRE |
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