Clinical Implications of Microsatellite Instability in Early Gastric Cancer
| Autor: | Ji Yeong An, Hyunki Kim, Chul Kyu Roh, Jae Ho Cheong, Taeil Son, Sung Hoon Noh, Yoon Young Choi, Dong Gyu Kim, Seohee Choi, Won Jun Seo, Hyoung Il Kim, Minah Cho, Su Jin Shin, Woo Jin Hyung |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Cancer Research
medicine.medical_specialty Lymphovascular invasion Gastroenterology Metastasis 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Stage (cooking) Lymph node Lymph nodes business.industry Hazard ratio Microsatellite instability Cancer medicine.disease Prognosis digestive system diseases Early Gastric Cancer medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Original Article business Gastric cancer |
| Zdroj: | Journal of Gastric Cancer |
| ISSN: | 2093-5641 2093-582X |
| Popis: | Purpose We aimed to evaluate the clinical characteristics of microsatellite instability in early gastric cancer. Materials and Methods The microsatellite instability status of resected early gastric tumors was evaluated using two mononucleotide repeat markers (BAT25 and BAT26) and three dinucleotide repeat markers (D5S346, D2S123, and D17S250). Tumors with instability in two or more markers were defined as microsatellite instability-high (MSI-H) and others were classified as microsatellite stable (MSS). Results Overall, 1,156 tumors were included in the analysis, with 85 (7.4%) classified as MSI-H compared with MSS tumors. For MSI-H tumors, there was a significant correlation with the female sex, older age, tumor location in the lower gastric body, intestinal histology, lymphovascular invasion (LVI), and submucosal invasion (P |
| Databáze: | OpenAIRE |
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