Pathological identification of brain tumors based on the characteristics of molecular fragments generated by laser ablation combined with a spiking neural network
| Autor: | Qianqian Wang, M. Nouman Khan, Kai Wei, Geer Teng, Wenting Xiangli, Haifeng Yang, Xutai Cui, Hongwei Zhang, Bushra Sana Idrees, Xueling Qi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Brain tumor resection
Hemangiopericytoma Spiking neural network Waiting time 0303 health sciences Laser ablation Computer science business.industry Pattern recognition Diagnostic accuracy medicine.disease 01 natural sciences Article Atomic and Molecular Physics and Optics 010309 optics Meningioma 03 medical and health sciences Glioma 0103 physical sciences medicine Artificial intelligence business 030304 developmental biology Biotechnology |
| Zdroj: | Biomed Opt Express |
| ISSN: | 2156-7085 |
| DOI: | 10.1364/boe.397268 |
| Popis: | Quick and accurate diagnosis helps shorten intraoperative waiting time and make a correct plan for the brain tumor resection. The common cryostat section method costs more than 10 minutes and the diagnostic accuracy depends on the sliced and frozen process and the experience of the pathologist. We propose the use of molecular fragment spectra (MFS) in laser-induced breakdown spectroscopy (LIBS) to identify different brain tumors. Formation mechanisms of MFS detected from brain tumors could be generalized into 3 categories, for instance, combination, reorganization and break. Four kinds of brain tumors (glioma, meningioma, hemangiopericytoma, and craniopharyngioma) from different patients were used as investigated samples. The spiking neural network (SNN) classifier was proposed to combine with the MFS (MFS-SNN) for the identification of brain tumors. SNN performed better than conventional machine learning methods for the analysis of similar and limited MFS information. With the ratio data type, the identification accuracy achieved 88.62% in 2 seconds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|