Cultured lung cells: interplay effects of beta-mimetics, prostaglandins and corticosteroids in the biosynthesis of dipalmitoyl lecithin
| Autor: | Apurba K. Ray, Giuseppe Colacicco, Robert M. Rosenbaum, Murray Wittner, Mukul K. Basu |
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| Rok vydání: | 1979 |
| Předmět: |
medicine.medical_specialty
food.ingredient Lung Neoplasms Hydrocortisone Biology Lecithin General Biochemistry Genetics and Molecular Biology Cell Line chemistry.chemical_compound food Biosynthesis Internal medicine medicine Choline Animals Humans Lung Ethanol Prostaglandins E Prostaglandins F Isoproterenol Pulmonary Surfactants medicine.disease Endocrinology medicine.anatomical_structure chemistry Cell culture Ritodrine Adenocarcinoma Rabbits medicine.drug |
| Zdroj: | Zeitschrift fur Naturforschung. Section C, Biosciences. 34(1-2) |
| ISSN: | 0341-0382 |
| Popis: | Cell lines derived from type II lung cells were used to study interplays of substances affecting incorporation of labeled precursors [1-14C] palmitate and [methyl-3H] choline into phosphatidyl choline. Ethanol stimulated markedly biosynthesis of dipalmitoyl phosphatidyl choline in cloned rabbit lung cells; the stimulating action of ethanol was reduced very much by cortisol and less by ritodrine. In the presence of 0.1 μᴍ isoproterenol, two prostaglandins, E2 and F2a, caused marked depressions in the incorporation of both precursors by cell line A 549 derived from human lung adenocarcinoma. One concluded that among the agents studied, ethanol and cortisol are potent antagonists, and so were also the prostaglandins and isoproterenol. |
| Databáze: | OpenAIRE |
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