Regulatory Myeloid Cells in Transplantation
| Autor: | Heth R. Turnquist, Brian R. Rosborough, Angus W. Thomson, Dàlia Raïch-Regué |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adoptive cell transfer
Myeloid Cell Survival Cell Transplantation medicine.medical_treatment T cell Cell Culture Techniques Biology Article Regulatory macrophages Immune tolerance Cell therapy Mice Cell Movement Immune Tolerance medicine Animals Humans Myeloid Cells Antigens Immunosuppression Therapy Inflammation Transplantation Macrophages Dendritic Cells Immunotherapy Adoptive Transfer Rats Cell biology medicine.anatomical_structure Leukocytes Mononuclear Transplantation Tolerance Immunosuppressive Agents |
| Zdroj: | Transplantation. 97:367-379 |
| ISSN: | 0041-1337 |
| Popis: | Regulatory myeloid cells (RMC) are emerging as novel targets for immunosuppressive (IS) agents and hold considerable promise as cellular therapeutic agents. Herein, we discuss the ability of regulatory macrophages (Mreg), regulatory dendritic cells (DCreg) and myeloid-derived suppressor cells (MDSC) to regulate alloimmunity, their potential as cellular therapeutic agents and the IS agents that target their function. We consider protocols for the generation of RMC and the selection of donor- or recipient-derived cells for adoptive cell therapy. Additionally, the issues of cell trafficking and antigen (Ag) specificity following RMC transfer are discussed. Improved understanding of the immunobiology of these cells has increased the possibility of moving RMC into the clinic to reduce the burden of current IS agents and promote Ag-specific tolerance. In the second half of this review, we discuss the influence of established and experimental IS agents on myeloid cell populations. IS agents believed historically to act primarily on T cell activation and proliferation are emerging as important regulators of RMC function. Better insights into the influence of IS agents on RMC will enhance our ability to develop cell therapy protocols to promote the function of these cells. Moreover, novel IS agents may be designed to target RMC in situ to promote Ag-specific immune regulation in transplantation and usher in a new era of immune modulation exploiting cells of myeloid origin. |
| Databáze: | OpenAIRE |
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