Intrauterine fetal demise in the third trimester of pregnancy associated with mild infection with the SARS-CoV-2 Delta variant without protection from vaccination
| Autor: | Minhui Guan, Eric Johannesen, Cynthia Y Tang, Albert L Hsu, Courtney L Barnes, Megan Burnam, Jane A McElroy, Xiu-Feng Wan |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2022 |
| Předmět: |
Delta variant
placenta SARS-CoV-2 Brief Report fungi coronavirus COVID-19 intrauterine fetal demise vaccination Infectious Disease Transmission Vertical acute inflammation Infectious Diseases AcademicSubjects/MED00290 Pregnancy embryonic structures cytokine storm Immunology and Allergy Humans Female Pregnancy Complications Infectious reproductive and urinary physiology |
| Zdroj: | The Journal of Infectious Diseases |
| ISSN: | 1537-6613 0022-1899 |
| Popis: | Background Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has a higher infection rate in pregnant women than age-matched adults. With increased infectivity and transmissibility, the Delta variant is predominant worldwide. Methods In this study, we describe intrauterine fetal demise in unvaccinated women with mild symptoms of SARS-CoV-2 Delta variant infection. Results Histology and elevated proinflammatory responses of the placenta suggest that fetal demise was associated with placental malperfusion due to Delta variant infection. Conclusions This study suggests that the Delta variant can cause severe morbidity and mortality to fetuses. Vaccination should continue to be advocated and will likely continue to reduce SARS-CoV-2 infection risks for pregnant women and their fetuses. |
| Databáze: | OpenAIRE |
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