Magnetoencephalographic Correlates of Emotional Processing in Major Depression Before and After Pharmacological Treatment
| Autor: | Christian Dobel, Kathrin Knoke, Volker Arolt, Christo Pantev, Katharina Domschke, Christian Steinberg, Maimu A. Rehbein, Peter Zwanzger, Isabelle A. G. Klinkenberg, Anette Kersting, Harald Kugel, Markus Junghöfer |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
MDD
medicine.medical_specialty Mirtazapine Temporoparietal junction temporoparietal junction Audiology Electroencephalography behavioral disciplines and activities IAPS 03 medical and health sciences 0302 clinical medicine medicine Pharmacology (medical) EEG ddc:610 Psychiatry Pharmacology Neural correlates of consciousness ddc:615 MEG medicine.diagnostic_test parietal hypoactivation Magnetoencephalography medicine.disease 030227 psychiatry Dorsolateral prefrontal cortex Psychiatry and Mental health medicine.anatomical_structure Antidepressant Major depressive disorder Psychology 030217 neurology & neurosurgery Research Article medicine.drug |
| Zdroj: | International Journal of Neuropsychopharmacology |
| Popis: | Background: In major depressive disorder (MDD), electrophysiological and imaging studies suggest reduced neural activity in the parietal and dorsolateral prefrontal cortex regions. In the present study, neural correlates of emotional processing in MDD were analyzed for the first time in a pre-/post-treatment design by means of magnetoencephalography (MEG), allowing for detecting temporal dynamics of brain activation. Methods: Twenty-five medication-free Caucasian in-patients with MDD and 25 matched controls underwent a baseline MEG session with passive viewing of pleasant, unpleasant, and neutral pictures. Fifteen patients were followed-up with a second MEG session after 4 weeks of antidepressant monopharmacotherapy with mirtazapine. The corresponding controls received no intervention between the measurements. The clinical course of depression was assessed using the Hamilton Depression scale. Results: Prior to treatment, an overall neocortical hypoactivation during emotional processing, particularly at the parietal regions and areas at the right temporoparietal junction, as well as abnormal valence-specific reactions at the right parietal and bilateral dorsolateral prefrontal cortex (dlPFC) regions were observed in patients compared to controls. These effects occurred |
| Databáze: | OpenAIRE |
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