| Autor: |
Darren Hargrave, Murray Yule, Melanie J. Griffin, Alan V. Boddy, John F. Lyons, Ana Rodriguez, Victoria Lock, Shamim Kazmi-Stokes, Philip Ross, Gary Acton, Sarah E.R. Halford, Guy Makin, Quentin Campbell-Hewson, Martin Elliott, Bruce Morland, Andrew D.J. Pearson, Lynley V. Marshall, Lucas Moreno |
| Rok vydání: |
2023 |
| DOI: |
10.1158/1078-0432.22460574 |
| Popis: |
Supplementary Table 1. Summary of pharmacodynamic changes observed in paired skin punch biopsies. Skin punch biopsies were optional until a dose limiting toxicity was found (11.5 mg/m2/day) when they were mandated. Inhibition of pHH3 (substrate for Aurora kinase B) can be observed in the majority of patients from the 11.5 mg/m2/day dose level. Decreases in Ki67 can be observed from the 18.5 mg/m2/day dose level. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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