Homotaurine Effects on Hippocampal Volume Loss and Episodic Memory in Amnestic Mild Cognitive Impairment

Autor: Anna Rosa Casini, Luca Cravello, Walter Gianni, Claudia Fratangeli, Giuseppe Sancesario, Gianfranco Spalletta, Claudia Cacciari, Maria Donata Orfei, Federica Piras, Carlo Caltagirone, Chiara Chiapponi, Mariangela Iorio, Fabrizio Piras
Rok vydání: 2016
Předmět:
Male
Taurine
Image Processing
Hippocampus
Neuropsychological Tests
Hippocampal formation
chemistry.chemical_compound
Computer-Assisted
0302 clinical medicine
80 and over
Image Processing
Computer-Assisted
Longitudinal Studies
030212 general & internal medicine
Amnestic mild cognitive impairment
episodic memory
hippocampus
homotaurine
structural magnetic resonance imaging
tramiprosate
Aged
Aged
80 and over
Analysis of Variance
Chi-Square Distribution
Cognitive Dysfunction
Female
Humans
Magnetic Resonance Imaging
Mental Status Schedule
Middle Aged
Neuroprotective Agents
Memory
Episodic
Psychiatry and Mental Health
Geriatrics and Gerontology
Clinical Psychology
Episodic memory
Temporal cortex
General Neuroscience
Neuropsychology
General Medicine
Psychiatry and Mental health
Homotaurine
Settore MED/26 - Neurologia
Episodic
Psychology
03 medical and health sciences
Memory
Fusiform gyrus
Brain morphometry
chemistry
Neuroscience
030217 neurology & neurosurgery
Zdroj: Journal of Alzheimer's Disease. 50:807-816
ISSN: 1875-8908
1387-2877
DOI: 10.3233/jad-150484
Popis: Homotaurine supplementation may have a positive effect on early Alzheimer's disease. Here, we investigated its potential neuroprotective effect on the hippocampus structure and episodic memory performances in amnestic mild cognitive impairment (aMCI). Neuropsychological, clinical, and neuroimaging assessment in 11 treated and 22 untreated patients were performed at baseline and after 1 year. Magnetic resonance data were analyzed using voxel-based morphometry to explore significant differences (Family Wise Error corrected) between the two groups over time. Patients treated with homotaurine showed decreased volume loss in the left and right hippocampal tail, left and right fusiform gyrus, and right inferior temporal cortex which was associated with improved short-term episodic memory performance as measured by the recency effect of the Rey 15-word list learning test immediate recall. Thus, homotaurine supplementation in individuals with aMCI has a positive effect on hippocampus atrophy and episodic memory loss. Future studies should further clarify the mechanisms of its effects on brain morphometry.
Databáze: OpenAIRE
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