The dopamine receptor D4 7-repeat allele influences neurocognitive functioning, but this effect is moderated by age and ADHD status: An exploratory study

Autor: Altink, M.E., Rommelse, N.N.J., Slaats-Willemse, D.I.E., Vasquez, A.A., Franke, B., Buschgens, C., Fliers, E.A., Faraone, S.V., Sergeant, J.A., Oosterkamp, T.H., Oosterlaan, J., Buitelaar, J.K.
Přispěvatelé: Other departments, Clinical Neuropsychology
Jazyk: angličtina
Rok vydání: 2012
Předmět:
Male
medicine.medical_specialty
Adolescent
Minisatellite Repeats
DCN PAC - Perception action and control
Neuropsychological Tests
Mental health [NCEBP 9]
Genomic disorders and inherited multi-system disorders DCN MP - Plasticity and memory [IGMD 3]
Young Adult
Cognition
Gene Frequency
Neuroimaging
SDG 3 - Good Health and Well-being
mental disorders
medicine
Dopamine receptor D4
Humans
Attention deficit hyperactivity disorder
Genetic Predisposition to Disease
DCN PAC - Perception action and control NCEBP 9 - Mental health
Allele
Child
Psychiatry
Biological Psychiatry
biology
Mechanism (biology)
Siblings
Receptors
Dopamine D4
Age Factors
Neuropsychology
Genomic disorders and inherited multi-system disorders [DCN PAC - Perception action and control IGMD 3]
medicine.disease
Psychiatry and Mental health
Attention Deficit Disorder with Hyperactivity
Case-Control Studies
Child
Preschool
Endophenotype
biology.protein
Female
Psychology
Neurocognitive
Zdroj: World Journal of Biological Psychiatry, 13, 4, pp. 293-305
World Journal of Biological Psychiatry, 13, 293-305
world journal of biological psychiatry, 13(4), 293-305. Taylor and Francis Ltd.
Altink, M E, Rommelse, N N J, Slaats-Willemse, D I E, Vasquez, A A, Franke, B, Buschgens, C, Fliers, E A, Faraone, S V, Sergeant, J A, Oosterkamp, T H, Oosterlaan, J & Buitelaar, J K 2012, ' The dopamine receptor D4 7-repeat allele influences neurocognitive functioning, but this effect is moderated by age and ADHD status: An exploratory study ', World Journal of Biological Psychiatry, vol. 13, no. 4, pp. 293-305 . https://doi.org/10.3109/15622975.2011.595822
World Journal of Biological Psychiatry, 13(4), 293-305. Informa Healthcare
ResearcherID
ISSN: 1562-2975
DOI: 10.3109/15622975.2011.595822
Popis: Item does not contain fulltext OBJECTIVES: Evidence suggests the involvement of the dopamine D4 receptor gene (DRD4) in the pathogenesis of ADHD, but the exact mechanism is not well understood. Earlier reports on the effects of DRD4 polymorphisms on neurocognitive and neuroimaging measures are inconsistent. This study investigated the functional consequences of the 7-repeat allele of DRD4 on neurocognitive endophenotypes of ADHD in the Dutch subsample of the International Multicenter ADHD Genetics study. METHODS: Participants were 350 children (5-11.5 years) and adolescents (11.6-19 years) with ADHD and their 195 non-affected siblings. An overall measure of neuropsychological functioning was derived by principal component analysis from five neurocognitive and five motor tasks. The effects of DRD4 and age were examined using Linear Mixed Model analyses. RESULTS: The analyses were stratified for affected and non-affected participants after finding a significant three-way interaction between ADHD status, age and the 7-repeat allele. Apart from a main effect of age, a significant interaction effect of age and DRD4 was found in non-affected but not in affected participants, with non-affected adolescent carriers of the 7-repeat allele showing worse neuropsychological performance. In addition, carrying the 7-repeat allele of DRD4 was related to a significantly worse performance on verbal working memory in non-affected siblings, independent of age. CONCLUSIONS: These results might indicate that the effect of the DRD4 7-repeat allele on neuropsychological functioning is dependent on age and ADHD status.
Databáze: OpenAIRE
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