Effects of GABA derivative TZ-50-2 on the autonomic nervous system
| Autor: | P. A. Galenko-Yaroshevskii, B. L. Popkov, S. N. Linchenko, Yu. P. Sheikh-Zade, A. V. Uvarov, I. L. Cherednik |
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| Předmět: |
medicine.medical_specialty
CATS Nerve Transmission Local anesthetic medicine.drug_class General Medicine General Biochemistry Genetics and Molecular Biology Cytisine chemistry.chemical_compound Autonomic nervous system Endocrinology chemistry Internal medicine medicine Derivative (chemistry) Adrenal chromaffin |
| Zdroj: | Scopus-Elsevier |
| Popis: | GABA derivative TZ-50-2 (4-oxy-3-benzylamino-N-benzylbutanamide hemisuccinate) with pronounced neurotropic (anticonvulsive and local anesthetic) and cardiotonic (antiarrhythmic and antianginal) activities produced a transient facilitation followed by a long-term inhibition of nerve transmission in the parasympathetic and, especially, sympathetic ganglia in acute experiments on cats. TZ-50-2 reduced sensitivity of adrenal chromaffin cells and cholinoreceptors of the carotid glomeruli to cytisine. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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