The incidence, risk factors, and outcomes of primary poor graft function after unmanipulated haploidentical stem cell transplantation

Autor: Wei Han, Feng-Rong Wang, Lan-Ping Xu, Xiao-Hui Zhang, Jing-Zhi Wang, Yu-Qian Sun, Gan-Lin He, Xiao-Jun Huang, Yu-Hong Chen, Huan Chen, Yu Wang, Ying-Jun Chang, Kai-Yan Liu
Rok vydání: 2015
Předmět:
Zdroj: Annals of Hematology. 94:1699-1705
ISSN: 1432-0584
0939-5555
DOI: 10.1007/s00277-015-2440-x
Popis: Primary poor graft function (PGF) is a severe complication after allogeneic stem cell transplantation (SCT). The incidence, risk factors, and outcomes of PGF have not been well described, especially in the haploidentical SCT setting. We retrospectively reviewed patients who received haploidentical SCT at Peking University Institute of Hematology between January 1, 2011, and December 31, 2012. PGF was defined as persistent neutropenia (≤0.5 × 10(9) L(-1)), thrombocytopenia (platelets ≤20 × 10(9) L(-1)), and/or hemoglobin ≤70 g L(-1) after engraftment with hypocellular bone marrow and full donor chimerism, without concurrent graft-versus-host disease or disease relapse. Incidence was calculated from all patients. Of the 464 total patients, 26 (5.6 %) developed primary PGF. The risk factors were analyzed and compared with control patients with good graft function who were selected using the case-pair method. Finally, 104 patients were selected as a control group according to the matching conditions: (1) the type (acute leukemia, myelodysplastic syndrome (MDS), chronic myelogenous leukemia (CML)) and status (standard risk, high risk) of underlying disease, (2) sex, (3) year in which the transplantation was received, and (4) a 1:4 ratio of case-control. No factors were found to be associated with primary PGF. Compared to cases with good graft function, patients with primary PGF experienced poor overall survival (34.6 vs. 82.7 %, p 0.001). Of the 26 primary PGF patients, only nine achieved hematopoietic recovery and survived. In conclusion, primary PGF is a rare but life-threatening complication after haploidentical SCT, and effective therapies need to be explored.
Databáze: OpenAIRE
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