Association between immunoglobulin allotypes and immune responses to Haemophilus influenzae and Meningococcus polysaccharides
| Autor: | Catherine U. Kyong, C.B. Loadholt, J.C. Parke, Janardan P. Pandey, Robert M. Galbraith, Emil C. Gotschlich, Gabriel Virella, H. Hugh Fudenberg |
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| Rok vydání: | 1979 |
| Předmět: |
Isoantigens
Immunoglobulin Allotypes Diphtheria Toxoid Genes MHC Class II Black People Immunoglobulins Biology Neisseria meningitidis Polysaccharide medicine.disease_cause Group A White People Microbiology Haemophilus influenzae Immune system Antigen medicine Tetanus Toxoid Humans chemistry.chemical_classification Pertussis Vaccine Polysaccharides Bacterial Infant General Medicine Antibodies Bacterial Allotype Phenotype chemistry Immunology Bacterial Vaccines biology.protein Antibody |
| Zdroj: | Lancet (London, England). 1(8109) |
| ISSN: | 0140-6736 |
| Popis: | Serum samples were collected from 20 healthy White and 33 Black infants before and after immunisation with three doses of diphtheria-pertussis-tetanus vaccine and with one dose of Haemophilus influenzae type b polyribose phosphate vaccine and meningococcal group A and group C polysaccharide vaccines. Antibodies to these immunogens were measured and sera were allotyped for several Gm, A2m, and Km antigens. A highly significant association was found between the Km(1) allotype and the immune responses (difference between post-immunisation and pre-immunisation antibody levels) to H. influenzae and meningococcus C polysaccharides in the White children. |
| Databáze: | OpenAIRE |
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