Serum levels of IL-12, IL-18, and IL-21 are indicators of viral load in patients chronically infected with HBV
| Autor: | Fangye Zhou, Haoran Xiong, Shenghang Zhen, Aimin Chen, Min Huang, Yupeng Luo |
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| Rok vydání: | 2022 |
| Předmět: |
Hepatitis B virus
Hepatitis B Surface Antigens Physiology General Neuroscience Interleukins Immunology Biophysics Interleukin-18 Ocean Engineering Alanine Transaminase Cell Biology General Medicine Chronic hepatitis B virus patients HBV-DNA loads Viral Load Biochemistry Interleukin-12 Hepatitis B Chronic DNA Viral Acetylcholinesterase Humans General Pharmacology Toxicology and Pharmaceutics |
| Zdroj: | Brazilian Journal of Medical and Biological Research v.55 2022 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC Brazilian Journal of Medical and Biological Research, Volume: 55, Article number: e12320, Published: 11 NOV 2022 |
| ISSN: | 1414-431X |
| Popis: | This study explored the correlation between interleukins (IL)-12, IL-18, and IL-21 and the viral load in patients with chronic hepatitis B virus (HBV). A total of 142 patients were consecutively enrolled. All were hepatitis B surface antigen (HBsAg)-positive for >6 months and did not receive drug therapy. An ELISA kit was used to test the IL-12, IL-18, IL-21, and acetylcholinesterase (AchE) levels in serum samples from chronic HBV patients and healthy control groups. The amounts of IL-12 and IL-18 were highest in the 5-6log10 (high viral load) group, while IL-21 was highest in the 3-4log10 (low viral load) group. Also, the IL-21 amount was decreased in the HBsAg+/HBeAg/HBcAb+ group, and IL-12, IL-18, and IL-21 were decreased in the normal alanine aminotransferase (ALT) group compared to the abnormal ALT group. These data suggested that IL-12, IL-18, and IL-21 serum levels were positively correlated with disease progression and could reflect disease severity for different HBV-DNA loads. Detection of IL-12, IL-18, and IL-21 levels was found to be helpful for evaluating the degree of liver cell damage and predicting the progression of hepatitis. |
| Databáze: | OpenAIRE |
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