| Autor: |
Upendra Chalise, Michael J. Daseke, William J. Kalusche, Shelby R. Konfrst, Jocelyn R. Rodriguez-Paar, Elizabeth R. Flynn, Leah M. Cook, Mediha Becirovic-Agic, Merry L. Lindsey |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Molecular Omics. 18:186-195 |
| ISSN: |
2515-4184 |
| DOI: |
10.1039/d1mo00519g |
| Popis: |
Inflammation presides early after myocardial infarction (MI) as a key event in cardiac wound healing. Ischemic cardiomyocytes secrete inflammatory cues to stimulate infiltration of leukocytes, predominantly macrophages and neutrophils. Infiltrating neutrophils degranulate to release a series of proteases including matrix metalloproteinase (MMP)-9 to break down extracellular matrix and remove necrotic myocytes to create space for the infarct scar to form. While neutrophil to macrophage communication has been explored, the reverse has been understudied. We used a proteomics approach to catalogue the macrophage secretome at MI day 1. Murinoglobulin-1 (MUG1) was the highest-ranked secreted protein (4.1-fold upregulated at MI day 1 |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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