Bacterial Pneumonias in Immunocompromised Patients
Autor: | Elie Azoulay, Andry Van de Louw, Adrien Mirouse, Virginie Lemiale, Olivier Peyrony |
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Rok vydání: | 2019 |
Předmět: |
Pulmonary and Respiratory Medicine
medicine.medical_specialty medicine.medical_treatment Population 030204 cardiovascular system & hematology Critical Care and Intensive Care Medicine law.invention 03 medical and health sciences Immunocompromised Host 0302 clinical medicine Cancer Survivors law Risk Factors Epidemiology medicine Pneumonia Bacterial Humans Intensive care medicine education education.field_of_study Cross Infection business.industry Bacterial pneumonia Immunosuppression medicine.disease Intensive care unit Review article Anti-Bacterial Agents Pneumonia 030228 respiratory system Respiratory failure business |
Zdroj: | Seminars in respiratory and critical care medicine. 40(4) |
ISSN: | 1098-9048 |
Popis: | With the overall improvement in survival of cancer patients and the widespread use of novel immunotherapy drugs for malignant as well as nonmalignant diseases, the prevalence of immunosuppression is rising in the population. Immunocompromised patients are particularly exposed to pulmonary infections which remain a leading cause for acute hypoxic respiratory failure and intensive care unit admission. Although fungal or opportunistic infections are always a concern, bacterial pneumonia remains the most common cause of pulmonary infection, is associated with a significant mortality, and has some specificity in this population. Adequate and timely prevention, diagnosis, and management of bacterial pneumonias require knowledge about the complex interplay between host factors (type and severity of immunosuppression) and bacterial pathogenesis, to improve the outcome. We provide an overview of bacterial pneumonias in immunocompromised patients including their epidemiology, risk factors with respect to the pattern of immunosuppression, microbiological characteristics, diagnostic approach, management, and prevention. |
Databáze: | OpenAIRE |
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