Novel metabotropic glutamate receptor 2/3 antagonists and their therapeutic applications: a patent review (2005 – present)
| Autor: | Iyassu K. Sebhat, Sylvain Celanire, Stephan Schann, Silvia Gatti, Stanislas Mayer, Juergen Wichmann |
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| Rok vydání: | 2014 |
| Předmět: |
Pharmacology
Drug Industry Molecular Structure business.industry Group ii Glutamate receptor General Medicine Receptors Metabotropic Glutamate Glutamate antagonists Review article Patents as Topic Structure-Activity Relationship Central Nervous System Diseases Metabotropic glutamate receptor Drug Design Drug Discovery Animals Humans Medicine Metabotropic glutamate receptor 2 business Excitatory Amino Acid Antagonists Neuroscience Signal Transduction |
| Zdroj: | Expert Opinion on Therapeutic Patents. 25:69-90 |
| ISSN: | 1744-7674 1354-3776 |
| DOI: | 10.1517/13543776.2014.983899 |
| Popis: | This review focuses on the medicinal chemistry efforts directed toward the identification of competitive and noncompetitive antagonists of glutamate at group II metabotropic glutamate receptors (mGluRII: mGlu2/3 and mGlu2). This class of compounds holds promise for the treatment of CNS disorders such as major depression, cognitive deficits and sleep-wake disorders, and several pharmaceutical companies are advancing mGluRII antagonists from discovery research into clinical development.This review article covers for the first time the patent applications that were published on mGlu2/3 orthosteric and allosteric antagonists between January 2005 and September 2014, with support from the primary literature, posters and oral communications from international congresses. Patent applications published prior to 2005 for which compositions of matter were largely described in peer review articles are briefly discussed with main findings.Recent advances in the prodrug approach of novel mGlu2/3 orthosteric antagonists combined with the design of novel mGlu2/3 and mGlu2 negative allosteric modulators provide new therapeutic opportunities for neurologic and psychiatric disorders. |
| Databáze: | OpenAIRE |
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