The age modification to leukocyte telomere length effect on bone mineral density and osteoporosis among Chinese elderly women
| Autor: | Qin Huang, Rui Yang, Qi Wang, Lailin Tao, Xiaolong Li, Can Li, Yu Dai, Yun Zeng, Junchao Zeng |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism Osteoporosis 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Endocrinology Asian People Bone Density Internal medicine medicine Leukocytes Humans Orthopedics and Sports Medicine Femoral neck Aged Bone mineral Sex Characteristics business.industry Absolute risk reduction Age Factors Telomere Homeostasis General Medicine Telomere medicine.disease Skeleton (computer programming) Osteopenia medicine.anatomical_structure Orthopedic surgery Linear Models Female 030101 anatomy & morphology Ordered logit business |
| Zdroj: | Journal of bone and mineral metabolism. 37(6) |
| ISSN: | 1435-5604 |
| Popis: | Critically short telomeres indicate cellular senescence. Leukocyte telomere length (LTL) is regarded as an aging predictor. Osteoporosis is an age-related disease. The purpose of our study is to examine the association between LTL, and BMD and osteoporosis among an elderly Chinese population. A total of 1017 participants (584 postmenopausal women) with a mean age of 66.4 years were recruited from April 2016 to August 2017. Dual-energy X-ray absorptiometry was used for BMD measurement at skeleton sites of lumbar spine (LS), femoral neck (FN), and total hip (TH). LTL was measured using quantitative real-time polymerase chain reaction. Among women, age significantly modified the effect of LTL on BMD at FN. Additionally, significant age modification was observed for the association between LTL and LS BMD category (indicative of control or osteopenia or osteoporosis), and the number of osteoporotic sites at LS or TH. The corresponding estimates (95% CI) for the relative excess risk due to interaction (RERI) were − 0.07 (− 0.11, − 0.01) and − 0.11 (− 0.16, − 0.03) sequentially in ordinal logistic regression models. The estimated RERIs (95% CI) were − 0.11 (− 0.25, − 0.02) and − 0.23 (− 0.39, − 0.10) in multinomial logistic regression models for LS/FN/TH BMD category, and − 0.20 (− 0.31, − 0.09) and − 0.34 (− 0.49, − 0.21) for FN BMD category. However, similar findings did not show in men. The effect of LTL on BMD and osteoporosis risk is modified by age in elderly women but not in men, suggesting that the predictive role of LTL in bone loss differs by sex. |
| Databáze: | OpenAIRE |
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