Causative drugs for drug-induced cutaneous reactions in central China: a 608-case analysis
| Autor: | Jun Zhao, Lei Hu, Lihua Zhang, Maosong Zhou, Lichen Gao, Lin Cheng |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
Antibiotics
Traditional Chinese medicine Pharmacovigilance 030207 dermatology & venereal diseases 0302 clinical medicine Hypnotics and Sedatives Medicine Child media_common Aged 80 and over Incidence Incidence (epidemiology) Age Factors Middle Aged Anti-Bacterial Agents RL1-803 Child Preschool 030220 oncology & carcinogenesis Anticonvulsants Drug hypersensitivity medicine.drug Adult Drug China medicine.medical_specialty Adolescent Drug-induced cutaneous adverse reactions medicine.drug_class media_common.quotation_subject Allopurinol Central china Dermatology Young Adult 03 medical and health sciences Age Distribution Humans Drug-induced severe cutaneous adverse reactions Sex Distribution Aged Retrospective Studies Investigation business.industry Drug eruptions Infant Carbamazepine medicine.disease business Adverse drug reaction |
| Zdroj: | Anais Brasileiros de Dermatologia Anais Brasileiros de Dermatologia, Vol 94, Iss 6, Pp 664-670 (2020) Anais Brasileiros de Dermatologia v.94 n.6 2019 Anais brasileiros de dermatologia Sociedade Brasileira de Dermatologia (SBD) instacron:SBD |
| ISSN: | 0365-0596 |
| DOI: | 10.1016/j.abd.2019.01.007 |
| Popis: | Background Reports regarding the causative drugs of drug-induced cutaneous adverse reactions in China are indistinct, such that different regions have reported the spectrum of drugs differs substantially in different clinical conditions. Objective To explore the causative drugs that led to cutaneous reactions. Methods Adverse drug reaction reports from central China were collected and divided into cutaneous adverse reactions and severe cutaneous adverse reactions groups. Cases were reviewed retrospectively for causative drugs. Results The male:female ratio was equal in both cutaneous adverse reactions and severe cutaneous adverse reactions. In cutaneous adverse reactions (n = 482), the highest incidence happened between 51 and 60 years of age and the top three causative drugs were antibiotics (48%), Chinese medicine (16%), and allopurinol (9%). In severe cutaneous adverse reactions (n = 126), the highest incidence happened between 41 and 50 years of age and the top three causative drugs were sedative-hypnotics and antiepileptics (39%), antibiotics (22%), and allopurinol (15%). Carbamazepine was the most frequently used single-drug (16/18) in sedative-hypnotics and antiepileptics. β-lactams were the most frequently used antibiotics that induced both cutaneous adverse reactions and severe cutaneous adverse reactions. Study limitations The small sample size, retrospective design, collection of cutaneous adverse reactions and severe cutaneous adverse reactions at different time frames and locations, and exclusion of patients taking more than five medications are limitations of the study. Conclusions Gender does not affect cutaneous adverse reactions and severe cutaneous adverse reactions. The top three drugs to induce cutaneous adverse reactions are antibiotics, Chinese medicine, and allopurinol, while those that triggered severe cutaneous adverse reactions are sedative-hypnotics and antiepileptics, antibiotics, and allopurinol. Carbamazepine is the most frequent single drug that induces severe cutaneous adverse reactions. β-lactams are the most frequently used antibiotics that induce both cutaneous adverse reactions and severe cutaneous adverse reactions. |
| Databáze: | OpenAIRE |
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