Predictors of Response to Endobronchial Coil Therapy in Patients With Advanced Emphysema
| Autor: | Dirk-Jan Slebos, Joseph Cicenia, Frank C. Sciurba, Gerard J. Criner, Jorine E. Hartman, Justin Garner, Gaëtan Deslée, Antoine Delage, Michael Jantz, Charles-Hugo Marquette, Charlie Strange, Umur Hatipoglu, Atul C. Mehta, Adam S. LaPrad, Gerald Schmid-Bindert, Felix J.F. Herth, Pallav L. Shah, F.J.F. Herth, D. Gompelmann, M. Schuhmann, R. Eberhardt, D. Harzheim, B. Rump, D.J. Slebos, N. Ten Hacken, K. Klooster, J.E. Hartman, S. Augustijn, P.L. Shah, C. Caneja, W. McNulty, J. Garner, G. Deslée, H. Vallerand, S. Dury, D. Gras, M. Verdier, C.H. Marquette, C. Sanfiorenzo, C. Clary, C. Leheron, J. Pradelli, S. Korzeniewski, P. Wolter, T. Arfi, F. Macone, M. Poudenx, S. Leroy, A. Guillemart, J. Griffonet, C. Strange, R. Argula, G. Silvestri, J.T. Huggins, N. Pastis, D. Woodford, L. Schwarz, D. Walker, G. Criner, J. Mamary, N. Marchetti, P. Desai, K. Shenoy, J.L. Garfield, J. Travaline, H. Criner, S. Srivastava-Malhotra, V. Tauch, R. Maxfield, K. Brenner, W. Bulman, B.A. Whippo, P.A. Jellen, R. Kalhan, C.T. Gillespie, S. Rosenberg, M. McAvoy DeCamp, A.S. Rogowski, J. Hixon, L.F. Angel, O. Dib, F.C. Sciurba, D. Chandra, M. Crespo, J. Bon Field, J. Rahul Tedrow, C. Ledezma, P. Consolaro, M. Beckner, A. Majid, G. Cheng, J. Cardenas-Garcia, D. Beach, E. Folch, A. Agnew, W. Hori, A. Nathanson, M. Wahidi, S. Shofer, M. Hartwig, K. Mahmood, E. Smathers, W. Tillis, K. Verma, D. Taneja, M. Peil, S. Chittivelu, P. Doloszycki, P.E. Whitten, B. Aulakh, O. Ikadios, J. Michel, J. Crabb, B. McVay, A. Scott, E.A. Pautler, T.A. Connolly, J.F. Santacruz, L. Kopas, R. Parham, B. Solid, W. Krimsky, F. Gregoire, S. King, A. Mehta, F. Almeida, T. Gildea, J. Cicenia, M. Machuzak, S. Sethi, Y.M. Meli, J. Baran, R. Rice, D. Faile, N. Rai, K. Jensen, R. Kahlstrom, A. Haroon, R. Ionita, F. White, D. Watkins, B. Moore, H. Soukiasian, H. Merry, Z. Mosenifar, S. Ghandehari, D. Balfe, J. Park, R. Mardirosian, J.S. Ferguson, J. Kanne, D. Sonetti, D. Modi, M. Regan, J. Maloney, M. Hackbarth, M. Gilles, A. Harris, A. Maser, J.T. Puchalski, C. Rochester, J. Possick, K. Johnson, Z. Dabre, K. Kovitz, M. Joo, J. DeLisa, S.V. Villalan, G. Krishna, J. Canfield, A. Marfatia, E. Selley, J. Utz, D. Midthun, R. Kern, E.S. Edell, L.L. Boras (née Kosok), S. Gay, K.A. Bauman, M. King Han, R.L. Sagana, K. Nelson, C. Meldrum, M. Jantz, H.J. Mehta, C. Eagan, J. West, A. Delage, S. Martel, P. LeBlanc, F. Maltais, Y. Lacasse, N. Lampron, F. Laberge, J. Milot, J. Picard, M.J. Breton, M. Dransfield, J.M. Wells, S. Bhatt, P. Smith, E.N. Seabron-Harris, K. Hammond, C. Egidio |
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| Přispěvatelé: | Groningen Research Institute for Asthma and COPD (GRIAC), Lifestyle Medicine (LM), University Medical Center Groningen [Groningen] (UMCG), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA), Space Research and Planetary Sciences [Bern) (WP), Physikalisches Institut [Bern], Universität Bern [Bern]-Universität Bern [Bern], Hôpital Maison Blanche, Centre Hospitalier Universitaire de Reims (CHU Reims), Pathologies Pulmonaires et Plasticité Cellulaire - UMR-S 1250 (P3CELL), Université de Reims Champagne-Ardenne (URCA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de Recherche sur le Cancer et le Vieillissement (IRCAN), Université Nice Sophia Antipolis (... - 2019) (UNS), COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015 - 2019) (COMUE UCA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université Côte d'Azur (UCA), Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (UNICANCER/CAL), UNICANCER-Université Côte d'Azur (UCA), Emory University [Atlanta, GA], IRT SystemX (IRT SystemX), Institute for Plasma Research, Bhat, Gandhinagar India, Department of Physics and Astronomy [Columbia], University of Missouri [Columbia], University of Missouri System-University of Missouri System, School of Electrical and Computer Engineering - Georgia Insitute of Technology (ECE GeorgiaTech), Georgia Institute of Technology [Atlanta], Institut für Informatik (LRR-TUM), Technische Universität München [München] (TUM), Université libre de Bruxelles (ULB), Département Recherches Subatomiques (DRS-IPHC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Louis Pasteur - Strasbourg I-Centre National de la Recherche Scientifique (CNRS), Royal Free Hospital, London, Los Alamos National Laboratory (LANL), Unité de pharmacochimie, School of Pharmaceutical, Université de Lausanne (UNIL), Institut de génétique humaine (IGH), Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS), Mullard Space Science Laboratory (MSSL), University College of London [London] (UCL) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Male
Internationality bronchoscopy [SDV]Life Sciences [q-bio] Critical Care and Intensive Care Medicine Logistic regression Radiography Interventional Severity of Illness Index Pulmonary function testing 0302 clinical medicine Quality of life Bronchoscopy lung volume reduction Medicine 030212 general & internal medicine Radiation treatment planning Pneumonectomy ComputingMilieux_MISCELLANEOUS COPD medicine.diagnostic_test Minimal clinically important difference Middle Aged Respiratory Function Tests Treatment Outcome emphysema Pulmonary Emphysema Female Radiology Cardiology and Cardiovascular Medicine Pulmonary and Respiratory Medicine medicine.medical_specialty Risk Assessment 03 medical and health sciences endobronchial coils Predictive Value of Tests Post-hoc analysis Humans Minimally Invasive Surgical Procedures Aged Analysis of Variance VALVES business.industry Patient Selection medicine.disease Logistic Models 030228 respiratory system Multivariate Analysis HRCT business Tomography X-Ray Computed Follow-Up Studies |
| Zdroj: | Chest, 155(5), 928-937. ELSEVIER SCIENCE BV Chest Chest, American College of Chest Physicians, 2019, 155 (5), pp.928-937. ⟨10.1016/j.chest.2019.02.012⟩ |
| ISSN: | 0012-3692 |
| Popis: | BACKGROUND: The Lung Volume Reduction Coil Treatment in Patients With Emphysema (RENEW) trial reported improvements in quality of life, pulmonary function, and exercise performance following endobronchial coil treatment.OBJECTIVES: The purpose of this post hoc analysis was to identify baseline predictors, including quantitative CT measures, that identify patients most likely to significantly benefit from endobronchial coil therapy.METHODS: Quantitative CT analysis by an independent radiology laboratory and a qualitative evaluation by five blinded experts of the baseline thoracic CT imaging were performed. Univariate and multivariate logistic regression analyses were performed to elucidate characteristics associated with clinical response.RESULTS: In total, 125 patients underwent coil treatment and had evaluable 12-month follow-up results. Of these, 78 patients received treatment of lobes with the highest emphysematous destruction determined by quantitative CT analysis (quantitative visual match [QVM]+), and 47 received treatment in at least one lobe that was not the most destroyed (QVM-). From the 78 patients with QVM+ treatment, a subgroup of 50 patients (64%) was identified with baseline residual volume > 200% predicted, emphysema score > 20% low attenuation area, and absence of airway disease. In this subgroup, greater lobar residual volume reduction in the treated lobes was achieved, which was associated with significant mean +/- SE improvement in FEV1 (15.2 +/- 3.1%), St. George's Respiratory Questionnaire (-12 +/- 2 points), and residual volume (-0.57 +/- 0.13 L).DISCUSSION: This post hoc analysis found that both significant hyperinflation (residual volume >= 200% predicted) and CT analysis are critical for patient selection and treatment planning for endobronchial coil therapy. Quantitative CT analysis is important to identify optimal lobar treatment and to exclude patients with insufficient emphysema ( |
| Databáze: | OpenAIRE |
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