Sero-prevalence and vaccination status of hepatitis A and hepatitis B among adults with cirrhosis in Sri Lanka: a hospital based cohort study
| Autor: | Hithanadura Janaka de Silva, Hasnatha Nuwan Karalliyadda, C.K. Ranawaka, Anuradha S Dassanayake, Vipuli Jayendra Kobbegala, Madunil A. Niriella, Arjuna P. De Silva |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Liver Cirrhosis Male HBsAg medicine.medical_specialty Alcoholic liver disease Cirrhosis Short Report lcsh:Medicine General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Seroepidemiologic Studies Internal medicine medicine Humans 030212 general & internal medicine lcsh:Science (General) lcsh:QH301-705.5 Sri Lanka Aged business.industry lcsh:R Vaccination Immunity virus diseases Hepatitis A General Medicine Hepatitis C Middle Aged biochemical phenomena metabolism and nutrition Hepatitis B medicine.disease digestive system diseases lcsh:Biology (General) Immunology Female 030211 gastroenterology & hepatology business Viral hepatitis lcsh:Q1-390 |
| Zdroj: | BMC Research Notes BMC Research Notes, Vol 10, Iss 1, Pp 1-3 (2017) |
| ISSN: | 1756-0500 |
| DOI: | 10.1186/s13104-017-2634-5 |
| Popis: | Background As acute viral hepatitis can be fatal in patients with cirrhosis, vaccination against hepatitis A (HAV) and hepatitis B (HBV) is recommended for non-immune patients. With increasing affluence the incidence of hepatitis A in childhood has decreased leading to a significant proportion of non-immune adults. As part of their routine investigation, hepatitis A IgG antibodies (anti-HAV IgG), hepatitis B surface antigen (HBsAg) and anti-HCV antibodies was checked and immunization status was assessed among consenting newly diagnosed cirrhotic patients presenting to a tertiary referral center. Findings Out of 135 patients, 107 [79.3%; males 91; mean age (SD) at presentation: 55.5 (11.6) years] with complete data were included for analysis. Most patients had either cryptogenic cirrhosis (62.6%) or alcoholic cirrhosis (29.9%); 2 (1.9%) had HBV cirrhosis, none had hepatitis C (HCV) cirrhosis. None of the patients had received vaccination against hepatitis A, while 71 (67.6%) had been vaccinated against HBV. The majority [62 (58%)] were negative for anti-HAV IgG. Conclusion Most cirrhotic patients in this cohort were not immune to hepatitis A. None had been vaccinated against HAV, while a third of patients had not been vaccinated against HBV. Cirrhotic patients should be routinely investigated for immunity against HAV and HBV, and vaccination offered to those found to be non-immune. |
| Databáze: | OpenAIRE |
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