Arugomycin, a new anthracycline antibiotic. III. Biological activities of arugomycin and its analogues obtained by chemical degradation and modification
| Autor: | Haruo Seto, Yoichi Hayakawa, Akihiro Shimosaka, Noboru Otake, Masaya Nakagawa, Hiroyuki Kawai, Nobuyasu Komeshima |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Myeloid
Magnetic Resonance Spectroscopy Anthracycline Chemical Phenomena Naphthacenes medicine.drug_class Antibiotics Biology Ehrlich ascites carcinoma Mice hemic and lymphatic diseases Drug Discovery Carcinoma medicine Animals Anthracyclines Leukemia L5178 Cytotoxicity Carcinoma Ehrlich Tumor Sarcoma 180 Pharmacology Antibiotics Antineoplastic Chemistry Physical Leukemia P388 Biological activity medicine.disease Leukemia Leukemia Myeloid Acute medicine.anatomical_structure Biochemistry Leukemia Erythroblastic Acute |
| Zdroj: | The Journal of antibiotics. 40(9) |
| ISSN: | 0021-8820 |
| Popis: | Biological activities of arugomycin and its analogues obtained by chemical degradation and modification were evaluated. Differences in the sugar moieties affected their biological activities including induction of differentiation of mouse Friend erythroleukemia cells and mouse myeloid leukemia cells, antitumor activities against sarcoma S-180, Ehrlich ascites carcinoma and P388 leukemia, and cytotoxicity against murine leukemia cells. Some relationships were found between the sugar moieties and biological activities. |
| Databáze: | OpenAIRE |
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