Xanthones from Swertia mussotii and Their α-Glycosidase Inhibitory Activities
| Autor: | Heru Chen, Shuang-Shuang Mao, Cheng Luo, Mao-xun Yang, Huan-huan Zheng, Cui-Ting Luo |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Gentianaceae
food.ingredient Glycoside Hydrolases Stereochemistry Xanthones Pharmaceutical Science Analytical Chemistry food Swertia mussotii Drug Discovery Medicinal plants Nuclear Magnetic Resonance Biomolecular IC50 Swertia Pharmacology chemistry.chemical_classification biology Traditional medicine Plant Extracts Organic Chemistry biology.organism_classification In vitro Enzyme Complementary and alternative medicine chemistry Alpha-glucosidase Herb biology.protein Molecular Medicine Software |
| Zdroj: | Planta Medica. 80:201-208 |
| ISSN: | 1439-0221 0032-0943 |
| Popis: | Two new xanthones, 1,8-dihydroxy-3-methoxyxanthone 7-O-[α-L-rhamnopyranosyl(1 → 2)-β-D-glucopyranoside] (1) and 1,8- dihydroxy-3-methoxyxanthone 7-O-[α-L-rhamnopyranosyl(1 → 3)-α-L-rhamno-pyranosyl (1 → 2)-β-D-xylopyranoside] (2), together with 26 known xanthones (3–28), were isolated from the aqueous ethanol extract of the traditional Chinese herb Swertia mussotii. Their structures were elucidated via spectroscopic analyses including 2D NMR. The inhibition of α-glucosidase by the isolated xanthones was evaluated by an in vitro high-throughput screening assay. Our results indicated that 1,3,5,8-tetrahydroxyxanthone is the best inhibitor with an IC50 value of 5.33 ± 0.09 µM, while the O-glycosylated xanthones were poor α-glycosidase inhibitors. |
| Databáze: | OpenAIRE |
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