House Dust Concentrations of Organophosphate Flame Retardants in Relation to Hormone Levels and Semen Quality Parameters

Autor: John D. Meeker, Heather M. Stapleton
Rok vydání: 2010
Předmět:
Male
Science Selections
Health
Toxicology and Mutagenesis
Tris(1
3-dichloro-2-propyl)phosphate
010501 environmental sciences
01 natural sciences
Toxicology
chemistry.chemical_compound
Risk Factors
Halogenated Diphenyl Ethers
Hormone metabolism
Testosterone Congeners
Flame Retardants
2. Zero hunger
Air Pollutants
0303 health sciences
Sperm Count
triphenyl phosphate
Organophosphate
Dust
Middle Aged
Spermatozoa
Organophosphates
3. Good health
Air Pollution
Indoor
Environmental chemistry
epidemiology
Triphenyl phosphate
Fire retardant
Adult
Phosphites
endocrine
Adolescent
TDCPP
Endocrine System
News
sperm
Young Adult
03 medical and health sciences
Organophosphorus Compounds
Semen
Humans
030304 developmental biology
0105 earth and related environmental sciences
Research
Public Health
Environmental and Occupational Health
Plasticizer
Environmental Exposure
Phosphate
Hormones
chemistry
exposure
DPHP
Zdroj: Environmental Health Perspectives
ISSN: 1552-9924
0091-6765
Popis: Background Organophosphate (OP) compounds, such as tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP), are commonly used as additive flame retardants and plasticizers in a wide range of materials. Although widespread human exposure to OP flame retardants is likely, there is a lack of human and animal data on potential health effects. Objective We explored relationships of TDCPP and TPP concentrations in house dust with hormone levels and semen quality parameters. Methods We analyzed house dust from 50 men recruited through a U.S. infertility clinic for TDCPP and TPP. Relationships with reproductive and thyroid hormone levels, as well as semen quality parameters, were assessed using crude and multivariable linear regression. Results TDCPP and TPP were detected in 96% and 98% of samples, respectively, with widely varying concentrations up to 1.8 mg/g. In models adjusted for age and body mass index, an interquartile range (IQR) increase in TDCPP was associated with a 3% [95% confidence interval (CI), −5% to −1%) decline in free thyroxine and a 17% (95% CI, 4–32%) increase in prolactin. There was a suggestive inverse association between TDCPP and free androgen index that became less evident in adjusted models. In the adjusted models, an IQR increase in TPP was associated with a 10% (95% CI, 2–19%) increase in prolactin and a 19% (95% CI, −30% to −5%) decrease in sperm concentration. Conclusion OP flame retardants may be associated with altered hormone levels and decreased semen quality in men. More research on sources and levels of human exposure to OP flame retardants and associated health outcomes are needed.
Databáze: OpenAIRE
Externí odkaz: