House Dust Concentrations of Organophosphate Flame Retardants in Relation to Hormone Levels and Semen Quality Parameters
Autor: | John D. Meeker, Heather M. Stapleton |
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Rok vydání: | 2010 |
Předmět: |
Male
Science Selections Health Toxicology and Mutagenesis Tris(1 3-dichloro-2-propyl)phosphate 010501 environmental sciences 01 natural sciences Toxicology chemistry.chemical_compound Risk Factors Halogenated Diphenyl Ethers Hormone metabolism Testosterone Congeners Flame Retardants 2. Zero hunger Air Pollutants 0303 health sciences Sperm Count triphenyl phosphate Organophosphate Dust Middle Aged Spermatozoa Organophosphates 3. Good health Air Pollution Indoor Environmental chemistry epidemiology Triphenyl phosphate Fire retardant Adult Phosphites endocrine Adolescent TDCPP Endocrine System News sperm Young Adult 03 medical and health sciences Organophosphorus Compounds Semen Humans 030304 developmental biology 0105 earth and related environmental sciences Research Public Health Environmental and Occupational Health Plasticizer Environmental Exposure Phosphate Hormones chemistry exposure DPHP |
Zdroj: | Environmental Health Perspectives |
ISSN: | 1552-9924 0091-6765 |
Popis: | Background Organophosphate (OP) compounds, such as tris(1,3-dichloro-2-propyl) phosphate (TDCPP) and triphenyl phosphate (TPP), are commonly used as additive flame retardants and plasticizers in a wide range of materials. Although widespread human exposure to OP flame retardants is likely, there is a lack of human and animal data on potential health effects. Objective We explored relationships of TDCPP and TPP concentrations in house dust with hormone levels and semen quality parameters. Methods We analyzed house dust from 50 men recruited through a U.S. infertility clinic for TDCPP and TPP. Relationships with reproductive and thyroid hormone levels, as well as semen quality parameters, were assessed using crude and multivariable linear regression. Results TDCPP and TPP were detected in 96% and 98% of samples, respectively, with widely varying concentrations up to 1.8 mg/g. In models adjusted for age and body mass index, an interquartile range (IQR) increase in TDCPP was associated with a 3% [95% confidence interval (CI), −5% to −1%) decline in free thyroxine and a 17% (95% CI, 4–32%) increase in prolactin. There was a suggestive inverse association between TDCPP and free androgen index that became less evident in adjusted models. In the adjusted models, an IQR increase in TPP was associated with a 10% (95% CI, 2–19%) increase in prolactin and a 19% (95% CI, −30% to −5%) decrease in sperm concentration. Conclusion OP flame retardants may be associated with altered hormone levels and decreased semen quality in men. More research on sources and levels of human exposure to OP flame retardants and associated health outcomes are needed. |
Databáze: | OpenAIRE |
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