The association between lactate and muscle aerobic substrate oxidation: Is lactate an early marker for metabolic disease in healthy subjects?
Autor: | Josh Yang, Charles J. Tanner, Nicholas T. Broskey, Walter J. Pories, Zhen W. Yang, G. Lynis Dohm, Ronald N. Cortright, Donghai Zheng, Nkaujyi Khang, Terry E. Jones, Joseph A. Houmard |
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Jazyk: | angličtina |
Rok vydání: | 2021 |
Předmět: |
medicine.medical_specialty
Physiology Health Status medicine.medical_treatment 030204 cardiovascular system & hematology Risk Assessment lcsh:Physiology Quadriceps Muscle Young Adult 03 medical and health sciences 0302 clinical medicine Waist–hip ratio Metabolic Diseases Predictive Value of Tests Physiology (medical) Internal medicine Humans Medicine Aerobic exercise Lactic Acid skeletal muscle Original Research aerobic fitness lactate lcsh:QP1-981 business.industry Insulin Cardiometabolic Risk Factors Skeletal muscle Cardiorespiratory fitness Metabolism Healthy Volunteers Mitochondria Muscle mitochondria Endocrinology medicine.anatomical_structure Cardiorespiratory Fitness Biomarker (medicine) Female Hemoglobin Energy Metabolism business metabolism Biomarkers 030217 neurology & neurosurgery Muscle Contraction |
Zdroj: | Physiological Reports, Vol 9, Iss 3, Pp n/a-n/a (2021) Physiological Reports |
Popis: | Fasting plasma lactate concentrations are elevated in individuals with metabolic disease. The aim of this study was to determine if the variance in fasting lactate concentrations were associated with factors linked with cardiometabolic health even in a young, lean cohort. Young (age 22 ± 0.5; N = 30) lean (BMI (22.4 ± 0.4 kg/m2) women were assessed for waist‐to‐hip ratio, aerobic capacity (VO2peak), skeletal muscle oxidative capacity (near infrared spectroscopy; fat oxidation from muscle biopsies), and fasting glucose and insulin (HOMA‐IR). Subjects had a mean fasting lactate of 0.9 ± 0.1 mmol/L. The rate of deoxygenation of hemoglobin/myoglobin (R 2 = .23, p = .03) in resting muscle and skeletal muscle homogenate fatty acid oxidation (R 2 = .72, p = .004) were inversely associated with fasting lactate. Likewise, cardiorespiratory fitness (time to exhaustion during the VO2peak test) was inversely associated with lactate (R 2 = .20, p = .05). Lactate concentration was inversely correlated with HDL:LDL (R 2 = .57, p = .02) and positively correlated with the waist to hip ratio (R 2 = .52, p = .02). Plasma lactate was associated with various indices of cardiometabolic health. Thus, early determination of fasting lactate concentration could become a common biomarker used for identifying individuals at early risk for metabolic diseases. In healthy subjects categorized as normal BMI, lactate was inversely related to skeletal muscle substrate oxidation. Additionally, lactate positively related to markers associated with metabolic disease risks. Lactate may be used as a clinical biomarker to identify patients at early risk for obesity. |
Databáze: | OpenAIRE |
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