The association between lactate and muscle aerobic substrate oxidation: Is lactate an early marker for metabolic disease in healthy subjects?

Autor: Josh Yang, Charles J. Tanner, Nicholas T. Broskey, Walter J. Pories, Zhen W. Yang, G. Lynis Dohm, Ronald N. Cortright, Donghai Zheng, Nkaujyi Khang, Terry E. Jones, Joseph A. Houmard
Jazyk: angličtina
Rok vydání: 2021
Předmět:
medicine.medical_specialty
Physiology
Health Status
medicine.medical_treatment
030204 cardiovascular system & hematology
Risk Assessment
lcsh:Physiology
Quadriceps Muscle
Young Adult
03 medical and health sciences
0302 clinical medicine
Waist–hip ratio
Metabolic Diseases
Predictive Value of Tests
Physiology (medical)
Internal medicine
Humans
Medicine
Aerobic exercise
Lactic Acid
skeletal muscle
Original Research
aerobic fitness
lactate
lcsh:QP1-981
business.industry
Insulin
Cardiometabolic Risk Factors
Skeletal muscle
Cardiorespiratory fitness
Metabolism
Healthy Volunteers
Mitochondria
Muscle
mitochondria
Endocrinology
medicine.anatomical_structure
Cardiorespiratory Fitness
Biomarker (medicine)
Female
Hemoglobin
Energy Metabolism
business
metabolism
Biomarkers
030217 neurology & neurosurgery
Muscle Contraction
Zdroj: Physiological Reports, Vol 9, Iss 3, Pp n/a-n/a (2021)
Physiological Reports
Popis: Fasting plasma lactate concentrations are elevated in individuals with metabolic disease. The aim of this study was to determine if the variance in fasting lactate concentrations were associated with factors linked with cardiometabolic health even in a young, lean cohort. Young (age 22 ± 0.5; N = 30) lean (BMI (22.4 ± 0.4 kg/m2) women were assessed for waist‐to‐hip ratio, aerobic capacity (VO2peak), skeletal muscle oxidative capacity (near infrared spectroscopy; fat oxidation from muscle biopsies), and fasting glucose and insulin (HOMA‐IR). Subjects had a mean fasting lactate of 0.9 ± 0.1 mmol/L. The rate of deoxygenation of hemoglobin/myoglobin (R 2 = .23, p = .03) in resting muscle and skeletal muscle homogenate fatty acid oxidation (R 2 = .72, p = .004) were inversely associated with fasting lactate. Likewise, cardiorespiratory fitness (time to exhaustion during the VO2peak test) was inversely associated with lactate (R 2 = .20, p = .05). Lactate concentration was inversely correlated with HDL:LDL (R 2 = .57, p = .02) and positively correlated with the waist to hip ratio (R 2 = .52, p = .02). Plasma lactate was associated with various indices of cardiometabolic health. Thus, early determination of fasting lactate concentration could become a common biomarker used for identifying individuals at early risk for metabolic diseases.
In healthy subjects categorized as normal BMI, lactate was inversely related to skeletal muscle substrate oxidation. Additionally, lactate positively related to markers associated with metabolic disease risks. Lactate may be used as a clinical biomarker to identify patients at early risk for obesity.
Databáze: OpenAIRE
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