Schizopeptin 791, a new anabeanopeptin-like cyclic peptide from the cyanobacterium Schizothrix sp
| Autor: | Vered Reshef, Shmuel Carmeli |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
Cyanobacteria
Stereochemistry Trypsin inhibitor Pharmaceutical Science High-performance liquid chromatography Peptides Cyclic Analytical Chemistry Schizopeptin 791 Drug Discovery Amino Acid Sequence Israel Spectral data Nuclear Magnetic Resonance Biomolecular Chromatography High Pressure Liquid Pharmacology chemistry.chemical_classification Chromatography biology Molecular Structure Organic Chemistry biology.organism_classification Cyclic peptide Complementary and alternative medicine chemistry Heteronuclear molecule Molecular Medicine Spectrophotometry Ultraviolet Trypsin Inhibitors Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | Journal of natural products. 65(8) |
| ISSN: | 0163-3864 |
| Popis: | Schizopeptin 791 (1), a new trypsin inhibitor, related in structure to the anabeanopeptins, was isolated from the hydrophilic extract of the cultured terrestrial cyanobacterium Schizothrix sp. Homo- and heteronuclear 2D NMR techniques as well as HRFABMS determined the gross structure of 1. The relative and absolute stereochemistry of 1 was deduced from a combination of spectral data and Marfey's method for HPLC. Prior to this finding, anabeanopeptins have been isolated only from water-bloom-forming strains of cyanobacteria. |
| Databáze: | OpenAIRE |
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