Stability-indicating assay for oxyphenbutazone. Part II. High-performance liquid chromatographic determination of oxyphenbutazone and its degradation products

Autor:	Andrianandrasana Ramiaramana, Marie-Dominique Blanchin, Bernadette Mandrou, Huguette Fabre
Rok vydání:	1986
Předmět:	Chromatography Chemistry Oxyphenbutazone Biochemistry Analytical Chemistry Drug Stability Stability indicating Electrochemistry medicine Environmental Chemistry Degradation (geology) Indicators and Reagents Spectroscopy Chromatography High Pressure Liquid medicine.drug
Zdroj:	The Analyst. 111(2)
ISSN:	0003-2654
Popis:	A high-performance liquid chromatographic method is proposed for the simultaneous determination of oxyphenbutazone and six potential decomposition products, using a reversed-phase column and ultraviolet detection. The method is more sensitive than thin-layer chromatography and allows the determination of 0.1% of each degradation product (with respect to oxyphenbutazone). It has been applied to the analysis of commercial tablets, capsules and ointments.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94f9cae3b7e90b979fdc92e1469e4525 https://pubmed.ncbi.nlm.nih.gov/3706758 Zobrazit plný text záznamu