Central analgesic effect of acetaminophen but not of aspirin
| Autor: | Hervé C Porchet, Pierre Piletta, Pierre Dayer |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male Analgesic Placebo Nociceptive flexion reflex Random Allocation chemistry.chemical_compound Double-Blind Method Threshold of pain medicine Humans Pharmacology (medical) Infusions Intravenous Propacetamol Acetaminophen Pain Measurement Pharmacology Aspirin business.industry digestive oral and skin physiology chemistry Anesthesia Transcutaneous Electric Nerve Stimulation Analysis of variance Analgesia business medicine.drug |
| Zdroj: | Clinical Pharmacology and Therapeutics. 49:350-354 |
| ISSN: | 1532-6535 0009-9236 |
| Popis: | The central nervous system effect of acetaminophen (paracetamol) and acetylsalicylic acid was investigated in healthy volunteers according to a crossover, double-blind, and placebo-controlled design. Ten subjects received, by intravenous route, a placebo, 1 gm acetaminophen, and 1 gm acetylsalicylic acid. Analgesia was assessed by measurement of the subjective pain threshold and the objective nociceptive flexion reflex threshold in response to selective transcutaneous electrical stimulations. A close correlation was observed between subjective and objective pain thresholds. Acetaminophen increased both thresholds for more than 4 hours (24% and 23% of baseline value at 120 minutes, respectively; p less than 0.001, ANOVA). In contrast, acetylsalicylic acid had no noticeable effect on either threshold. These findings show that acetaminophen-induced analgesia is centrally mediated, in contrast to aspirin. The time delay between plasma concentration kinetics and acetaminophen analgesic effect is another argument in favor of its direct action on the central nervous system. |
| Databáze: | OpenAIRE |
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