Development of Micro-Grippers for Tissue and Cell Manipulation with Direct Morphological Comparison
| Autor: | Alden Dochshanov, Matteo Verotti, Rocco Crescenzi, Enrico Sciubba, Nicola Pio Belfiore, Giovanna Razzano, Alvise Bagolini, Stefano Natali, Giovanni B. Broggiato, Rossana Cecchi, Roberto Capata, Pierluigi Bellutti, Marco Balucani, Franco Lucchese |
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| Přispěvatelé: | Cecchi, R., Verotti, M., Capata, R., Dochshanov, A. M., Broggiato, G. B., Crescenzi, R., Balucani, M., Natali, S., Razzano, G., Lucchese, F., Bagolini, A., Bellutti, P., Sciubba, E., Belfiore, N. P. |
| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: |
Engineering
cell manipulation media_common.quotation_subject lcsh:Mechanical engineering and machinery Hinge Microgripper Topology (electrical circuits) Degrees of freedom (mechanics) In vitro analysis Development (topology) lcsh:TJ1-1570 Electrical and Electronic Engineering Function (engineering) media_common Microelectromechanical systems business.industry Mechanical Engineering Cell manipulation tissue manipulation Control engineering MEMS Tissue manipulation Control and Systems Engineering Grippers microgripper business |
| Zdroj: | Micromachines, Vol 6, Iss 11, Pp 1710-1728 (2015) Micromachines; Volume 6; Issue 11; Pages: 1710-1728 Micromachines Volume 6 Issue 11 Pages 1710-1728 |
| Popis: | Although tissue and cell manipulation nowadays is a common task in biomedical analysis, there are still many different ways to accomplish it, most of which are still not sufficiently general, inexpensive, accurate, efficient or effective. Several problems arise both for in vivo or in vitro analysis, such as the maximum overall size of the device and the gripper jaws (like in minimally-invasive open biopsy) or very limited manipulating capability, degrees of freedom or dexterity (like in tissues or cell-handling operations). This paper presents a new approach to tissue and cell manipulation, which employs a conceptually new conjugate surfaces flexure hinge (CSFH) silicon MEMS-based technology micro-gripper that solves most of the above-mentioned problems. The article describes all of the phases of the development, including topology conception, structural design, simulation, construction, actuation testing and in vitro observation. The latter phase deals with the assessment of the function capability, which consists of taking a series of in vitro images by optical microscopy. They offer a direct morphological comparison between the gripper and a variety of tissues. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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