Discrepancy in the Shrinkage of Uterine Fibroids After Treatment with Gonadotropin Releasing Hormone Analogs
| Autor: | Yuen-Shan Lin, Chun-Chieh Chia, Soon-Cen Huang, Ching-Cheng Zheng, Shen-Shien Chen, Kuo-Feng Huang, Jye-Yi Kang, Jing-Chuan Lin |
|---|---|
| Jazyk: | angličtina |
| Předmět: |
Gynecology
medicine.medical_specialty Uterine fibroids business.industry Uterus Gonadotropin-releasing hormone medicine.disease female genital diseases and pregnancy complications medicine.anatomical_structure GnRHa shrinkage Volume (thermodynamics) Leuprorelin Radiology Nuclear Medicine and imaging medicine Radiology Nuclear Medicine and imaging uterine fibroids Nuclear medicine business Prospective cohort study After treatment Shrinkage medicine.drug |
| Zdroj: | Journal of Medical Ultrasound. (4):114-118 |
| ISSN: | 0929-6441 |
| DOI: | 10.1016/S0929-6441(09)60096-5 |
| Popis: | Background The purpose of this prospective study is to investigate the discrepancy in the volume of shrinkage of uterine fibroids after treatment with gonadotropin releasing hormone analogs (GnRHa). Materials and Methods Twenty-one patients, who were diagnosed as having a single uterine fibroid before any further intervention, were included. They received myomectomy after two complete doses of leuprorelin acetate 3.75 mg (Leuplin Depot), a GnRHa injected subcutaneously at an interval of 4 weeks. The vascularization index, flow index, vascularization-flow index, pulsative index, resistance index, vascular patterns (histogram), blood flows and sizes (volume and largest diameter) of each fibroid were measured with power Doppler every month before the operation. Results The mean volume of the pre-treated uterus and the fibroid was 473.8 cm 3 and 302.4 cm 3 , respectively. The mean decrease in the volume of the uterus and the fibroid was 97.3 cm 3 and 68.3 cm 3 , respectively. Fourteen patients had a significant decrease in the volume of the post-treated fibroid (mean percentage of decrease in volume was 43%). The decrease in volume was significant when the pre-treated fibroid volume was above 200 cm 3 . Conclusions From these results, the trend suggests that the larger the fibroid (> 200 cm 3 ), the greater the decrease in volume after treatment. The discrepancy in the volume of shrinkage of the fibroids may be due to their heterogenicity, which should be further investigated in the future. |
| Databáze: | OpenAIRE |
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